Biofilm formation is an important adaptation and survival strategy commonly employed by bacteria but, unfortunately, a major cause for infections in humans. Researchers have now demonstrated the safe removal of in vivo bacterial biofilms through artificial nanomotors driven by near-infrared laser light. This is the first demonstration of a self-propelled antibiofilm platform capable of conducting photothermal and antibiotic therapy in the deep layers of biofilm, achieving high therapeutic efficiency in vivo without damaging healthy tissues.