Cancer Research ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏
| | | | A major challenge for early detection and diagnosis research is the time it takes to generate evidence that screening and other interventions result in less cancer mortality.
A panel of experts coordinated by Cancer Research UK recently published a review in the Lancet Oncology, exploring the status of alternative surrogate endpoints for cancer mortality that could provide evidence of utility faster.
This is an ongoing priority area for us. Please contact us if you have any thoughts to help accelerate the discovery, validation and implementation of surrogate endpoints.
Congratulations to Rebecca Fitzgerald on becoming a newly elected Fellow of The Royal Society. Rebecca leads the Early Cancer Institute at the University of Cambridge and has conducted extensive research into oesophageal adenocarcinoma and the predisposing condition Barrett’s oesophagus. She has applied these insights to develop a diagnostic test for Barrett's oesophagus, with the technology currently being evaluated in the BEST4 trial.
Don’t miss out on our Early Detection of Cancer Conference taking place this October in San Francisco and grab your tickets now.
Kind regards
David Crosby
Head of Prevention and Early Detection Research
Cancer Research UK |
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| | Our Research Careers Committee is open to applications from early to mid-career clinical and non-clinical academics with a focus on early detection research.
Spread the word out and get prepared. |
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A role for surrogate endpoints in future cancer screening trials |
| What are the requirements/considerations for identifying an endpoint that can be measured earlier than disease-specific mortality and that could serve as the primary outcome?
“We need to consider the potential in using surrogates to accelerate the translational pathway where appropriate. We can stop trials of ineffective screening early and progress implementation research of promising screening strategies while awaiting cancer mortality results”, says Alexis Webb, a Research Programme Manager at Cancer Research UK.
In a recent publication in Lancet Oncology, Alexis and colleagues present the current landscape and challenges of using surrogate endpoints for cancer screening trials.
The authors also provide a framework that researchers can use when exploring the possibility of using surrogate endpoints. |
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| | #CRUKFunded: Blood proteins could predict cancer seven years before diagnosis |
| Keren Papier and colleagues have identified new links between blood proteins and different types of cancer.
The team identified 618 proteins linked to 19 different types of cancer, including 107 proteins in a group of people whose blood was collected at least seven years before diagnosis.
The findings published in Nature Communications suggest that some of these proteins could be used to detect cancer earlier.
In the future, this could also help treat the disease at a much earlier stage or prevent it altogether.
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Submit a nomination for the Don Listwin award this year |
| Don’t miss out on the opportunity to recognise a colleague or team who has contributed to the field of cancer early detection.
Nominate them for this year’s Don Listwin award to recognise and celebrate their work at our global early detection of cancer conference in October.
Past winners include members of our community such as Peter Sasieni and Rebecca Fitzgerald. |
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| | New funding call: Health Technologies Connectivity Awards |
| Are you looking for an opportunity to spend time in a different research environment to build connections within health technologies?
The Engineering and Physical Sciences Research Council (EPSRC) are providing grants up to £500k to address the following challenges: |
| | improving population health and prevention transforming prediction and early diagnosis discovering and accelerating the development of new interventions | In this pilot scheme, researchers will develop new skills and collaborations to progress their research in health technologies. |
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| | Send us your research photos |
| Our new image campaign – Research is beautiful – is now open for entries. We’re looking for captivating images that showcase your research. It could be your science from the microcosm to the macrocosm; you and your fellow researchers in action; as well as research environments spanning from the lab to research events. Anything that captures your work, or your passion for your work is welcome.
Email us your photos now. T&Cs apply.
Stay tuned to #ResearchIsBeautiful on our social media for our monthly picks. |
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| | | | | On the first day at our Cancer Prevention Research Conference, Salvatore Vaccarella (International Agency for Research on Cancer) and Chanita Hughes-Halbert (USC Norris Comprehensive Cancer Center) will be chairing a session on health inequities and prevention.
Join us to hear from Ophira Ginsburg (NCI), Tiffany Carson (Moffitt Cancer Center) and Samilia Obeng-Gyasi (The Ohio State University) highlighting the importance of preventative interventions to reduce inequities in cancer incidence and avoid any further exacerbation.
Grab your tickets for our conference in Boston from 25-27 June. | | |
| | | | | | | Peter Sasieni and colleagues have shown that the UK national HPV vaccination programme is associated with a reduction in cervical disease in all socioeconomic groups.
The study analysed cancer data from NHS England for vaccinated and unvaccinated women aged 20-64 years to examine if the already high HPV vaccination effectiveness continued in an additional year of follow-up.
The results published in the BMJ demonstrated a decrease of cervical cancer and grade 3 cervical intraepithelial neoplasia across all deprivation groups, especially in women offered routine vaccination.
This shows that well executed public health interventions can both improve health and reduce health inequalities. | | |
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Join us for a UK-Canada prevention research workshop |
| Calling mid-career and established researchers working in cancer prevention!
We are organising a 2-day international research workshop in collaboration with several Canadian cancer research funders on 5-6 September at Canada House, London.
This workshop will focus on the interplay between inflammation and obesity in cancer genesis, from the earliest deviation from ‘normal’ through dysplasia to cancer, which could inform future precision prevention approaches and/or predictive biomarker identification.
Don’t miss the opportunity to exchange knowledge and collaborate with our partners including the Canadian Cancer Society, Institute of Cancer Research, Cancer Research Society, Ontario Institute for Cancer Research and The Terry Fox Research Institute. |
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