Various types of gene editing techniques allow for an unprecedented ability to modify genes that can be used to develop cell and gene therapies for cancer. However, these modifications are not always expressed in a consistent way due to cell heterogeneity. Single-cell functional proteomics can help optimize cell and gene therapy development by allowing researchers to identify critical functional biomarkers for product quality and reveal the superhero cells that have correlated to potency, persistence, and response in various studies.
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