| Overnight insulin requirements were significantly more variable than daytime and total daily amounts. This may explain why some people with type 1 diabetes report frustrating variability in morning glycemia (Diabetes Care)
More patients treated with canagliflozin experienced reductions in both HbA1c and body weight compared with glimepiride for up to 104 weeks. Canagliflozin was generally well tolerated in patients with T2DM when used in combination with metformin (Diabetes Therapy)
The burgeoning diabetes population and promising advances in this field warrant continued investments and efforts to explore the utility of engineered gut cells in the treatment of diabetes (Journal of Diabetes Investigation)
Although the success of GLP-1 analogs/mimetics in the treatment of type 2 diabetes and the correlation of strongly elevated postprandial GLP-1 levels after Roux-Y gastric bypass surgery strongly suggests benefits of recruiting endogenous GLP-1 reserves as a not yet exploited treatment alternative, the situation for GIP is less clear (Journal of Diabetes Investigation)
In frail older people, particularly in those with chronic wasting diseases and significant weight loss, blood glucose levels tend to normalize with increased risk of hypoglycemia. Recurrent hypoglycemia in frail older people with diabetes is a marker of vulnerability and hypoglycemic medication review or even complete withdrawal is appropriate in this group of patients (Future Science)
Based on the effect of ileal transposition, we can conclude that the contribution of the distal small intestine to the metabolic benefits of bariatric/metabolic surgery is quite considerable (Journal of Diabetes Investigation)
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