Glycosmedia Weekly Diabetes News - 01/24/2020

Socio‐economic status and mortality in people with type 1 diabetes in Scotland 2006–2015: a retrospective cohort study

Socio‐economic deprivation was associated with a steeper mortality gradient in people with type 1 diabetes than in the population without type 1 diabetes in Scotland. Age‐standardized mortality has decreased over time but socio‐economic inequalities may be increasing. (Diabetic Medicine)

Empagliflozin Effectively Lowers Liver Fat Content in Well-Controlled Type 2 Diabetes: A Randomized, Double-Blind, Phase 4, Placebo-Controlled Trial

EMPA effectively reduces hepatic fat in patients with T2D with excellent glycemic control and short known disease duration. Interestingly, EMPA also decreases circulating uric acid and raises adiponectin levels despite unchanged insulin sensitivity. EMPA could therefore contribute to the early treatment of nonalcoholic fatty liver disease in T2D (Diabetes Care)

How Valid Are the New Hypoglycemia Definitions for Use in Clinical Trials?

The deeper analysis of data from the well-powered SWITCH studies does support that the new IHSG level 2 definition compared with the previous ADA definition can result in statistically more robust findings when comparing insulins (Diabetes Care)

Time to Include Nonalcoholic Steatohepatitis in the Management of Patients With Type 2 Diabetes

It is time to include NASH in the management plan of patients with T2D in the same way as today it includes diabetic retinopathy or nephropathy (Diabetes Care)

Guidelines of the international writing group on the diabetic foot on diagnosis

We here present the updated 2019 guidelines on diagnosis, prognosis, and management of PAD in patients with a foot ulcer and diabetes, and we suggest some key future topics of particular research interest (Diabetes/Metabolism Research and Reviews)

Comparative effects of sulfonylureas, DPP4is and SGLT2 inhibitors added to metformin monotherapy: a propensity‐score matched cohort study in UK primary care

In routine care, SGLT2is have greater effects on cardiometabolic risk factors than SUs. Routine care data closely replicates the effects of diabetes drugs on physiological variables measured in clinical trials (Diabetes, Obesity and Metabolism)

Standards of Medical Care in Diabetes—2020 Abridged for Primary Care Providers

The American Diabetes Association’s (ADA’s) Standards of Medical Care in Diabetes is updated and published annually in a supplement to the January issue of Diabetes Care

The future of prevention of diabetic foot ulcer: A paradigm shift from stratified healthcare towards personalized medicine

Diabetic foot ulcer prevention is still underexposed in research and clinical practice, despite that all working in diabetic foot care agree that it is highly important. In this article, we identified a number of barriers that, in our opinion, prevent prioritizing ulcer prevention (Diabetes/Metabolism Research and Reviews)