Glycosmedia Weekly Diabetes News Update
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Glycosmedia Weekly Diabetes News - 09/18/2020

Metformin in women with type 2 diabetes in pregnancy (MiTy): a multicentre, international, randomised, placebo-controlled trial

We found several maternal glycaemic and neonatal adiposity benefits in the metformin group. Along with reduced maternal weight gain and insulin dosage and improved glycaemic control, the lower adiposity and infant size measurements resulted in fewer large infants but a higher proportion of small-for-gestational-age infants (The Lancet Diabetes & Endocrinology)


Type 2 diabetes and metabolic surgery guidelines and recommendations should urgently be unified

A more harmonious discussion and unified guidelines between clinicians and surgeons are needed in order to provide the same message for those who read different articles (Acta Diabetologica)


Relationship of glycemic derangement using continuous glucose monitoring system with sleep pattern among children with type 1 diabetes mellitus

Clinically significant hypoglycemia is associated with sleep deepening, while hyperglycemia is associated with increased light sleep, sleep onset latency, AI among C‐T1D (Diabetes/Metabolism Research and Reviews)


Pharmacogenomic Studies of Current Antidiabetic Agents and Potential New Drug Targets for Precision Medicine of Diabetes

This review summarizes pharmacogenomic evidence of some current antidiabetic agents applied in clinical settings, and highlights potential drugs with new targets for diabetes, which represent a more effective treatment in the future (Diabetes Therapy)


Patrolling Monocytes Are Recruited and Activated By Diabetes To Protect Retinal Microvessels

Thus, after short diabetes duration, PMo are the cells preferentially recruited to the retinal vessels and protect vessels from diabetic damage (Diabetes)


Triglyceride-glucose index predicts independently type 2 diabetes mellitus risk: A systematic review and meta-analysis of cohort studies

TyG index has a positive and significant association with T2D risk, suggesting that the TyG index may become an applicable tool to identify subjects with T2D risk (Primary Care Diabetes)


Effect of sidt2 Gene on Cell Insulin Resistance and Its Molecular Mechanism

sidt2 knockout can reduce glucose uptake in peripheral tissue under insulin stimulation, which may lead to peripheral tissue insulin resistance by affecting the IRS-1 signal pathway (Journal of Diabetes Research)


An increase in inflammation and islet dysfunction is a feature of prediabetes

Based on our findings, inflammation and islet dysfunction may be more significant than originally thought in people with prediabetes. Rather than being in a normal state before diabetes occurs, it appears they are already in an early diabetic condition more closely resembling T2D (Diabetes/Metabolism Research and Reviews)


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Please visit the Glycosmedia website for more features and information, including:

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Comment on recently published papers written by the medical editors of Glycosmedia.

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Updates written by Professor Steve Bain (Diabetologist) and Dr. Mark Freeman (Diabetologist).

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