Glycosmedia Weekly Diabetes News - 05/21/2021

Rethinking pioglitazone as a cardioprotective agent: a new perspective on an overlooked drug

With appropriate prescription and titration, pioglitazone remains a useful tool in the arsenal of the clinical diabetologist (Cardiovascular Diabetology)

Metabolic surgery for type II diabetes: an update

High quality data from RCTs have clearly established that bariatric procedures are more effective than medical or lifestyle interventions for inducing weight loss and remission of type 2 diabetes, even in mild obese patients with a BMI between 30 and 35 kg/m2 (Acta Diabetologica)

Circulating short and medium chain fatty acids are associated with normoalbuminuria in type 1 diabetes of long duration

Our findings suggest that MCFAs and SCFAs contribute to the metabolic processes underlying protection against albuminuria development in T1D that are independent from mechanisms associated with changes in renal function (Nature)

Deficits in the Skeletal Muscle Transcriptome and Mitochondrial Coupling in Progressive Diabetes-Induced CKD Relate to Functional Decline

Our results indicate that T2DM-induced CKD progression impairs physical function, with implications for altered metabolic transcriptional networks and mitochondrial functional deficits as primary mechanistic factors early in CKD progression in T2DM (Diabetes)

The beneficial short‐term effects of a high‐protein/low‐carbohydrate diet on glycaemic control assessed by continuous glucose monitoring in patients with type 1 diabetes

Compared with REF and MED, an HPD plan may have a positive impact on glycaemic control in patients with T1D. During the HPD, patients spent a shorter time in hypoglycaemia and exhibited lower glycaemic variability (Diabetes, Obesity and Metabolism)

Incorporation of a genetics-based information module into standardized diabetes patient education

The educational module increased understanding of diabetes and increased motivation to adopt healthy behaviors (Primary Care Diabetes)