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Glycosmedia Weekly Diabetes News - 06/11/2021

Widening health inequalities related to Type 1 diabetes care in children and young people in the UK– a time to act now

The authors urge that research into barriers of access to technology for T1D in CYP in the UK specifically looking at provider bias, systemic issues within the health system, and individual and family factors are conducted with urgency (Diabetic Medicine)


Emerging Roles of Long Non-Coding RNAs in Diabetic Foot Ulcers

In this review, we briefly summarize the current knowledge regarding the functional roles and potential mechanisms of reported lncRNAs in regulating DFU (Dove Press)


Diagnostic value of combined islet antigen-reactive T cells and autoantibodies assays for type 1 diabetes mellitus

Enzyme-linked immunospot assays in combination with Abs detection could improve the diagnostic sensitivity of autoimmune diabetes (Journal of Diabetes Investigation)


Sodium–glucose cotransporter 2 inhibitors and risk of nephrolithiasis

Initiation of treatment  with SGLT2Is was associated with a clinically significant reduced risk of incident and recurrent nephrolithiasis (Diabetologia)


Comparing real-time and intermittently scanned continuous glucose monitoring in adults with type 1 diabetes (ALERTT1): a 6-month, prospective, multicentre, randomised controlled trial

In an unselected adult type 1 diabetes population, switching from isCGM to rtCGM significantly improved time in range after 6 months of treatment, implying that clinicians should consider rtCGM instead of isCGM to improve the health and quality of life of people with type 1 diabetes (The Lancet)


The association of laminin levels with insulin resistance and non-alcoholic hepatosteatosis

Our study results suggest that, although there is no exact link between laminin and non-alcoholic hepatosteatosis, serum laminin levels are lower in patients with insulin resistance by regulating the insulin effect through integrins (Diabetes and Metabolic Syndrome)


Serum albumin modifies the effect of peripheral blood monocytes on severity of diabetic nephropathy

Circulating monocytes and serum albumin are significantly associated with albuminuria, but not eGFR in DKD. These results support the potential role of the innate immune system in diabetic microvascular end-organ damage and urine protein loss, and may be readily translatable clinical markers to incorporate into risk-assessment models for prognostication in diabetes (Canadian Journal of Diabetes)


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Comment on recently published papers written by the medical editors of Glycosmedia.

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