Glycosmedia Weekly Diabetes News - 07/09/2021

Machine learning based study of longitudinal HbA1c trends and their association with all-cause mortality: Analyses from a National Diabetes Registry

HbA1c variability and trend are important determinants of mortality risk and should be considered when adjusting glycemic targets (Diabetes/Metabolism Research and Reviews)

Clinical characteristics, gestational weight gain and pregnancy outcomes in women with a history of gestational diabetes mellitus

Women with prior GDM have glucose and lipid metabolism disorders in the 1st trimester. Limited reduction of GWG before oral glucose tolerance test (OGTT) was insufficient to offset the adverse effects of glucose and lipid metabolism disorders in women with previous GDM (Diabetology & Metabolic Syndrome)

A cross sectional study to compare cardiac structure and diastolic function in adolescents and young adults with youth-onset type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth Study

LV structure and diastolic function is worse in individuals with T2D compared to T1D (Cardiovascular Diabetology)

Impact of SGLT2 inhibitors in comparison to DPP4 inhibitors on ascites and death in veterans with cirrhosis on metformin

In comparison to DPP4i, SGLT2i may improve survival for patients with cirrhosis who require additional pharmacotherapy for DM beyond metformin, but confirmatory studies are necessary (Diabetes, Obesity and Metabolism)

Facilitated Buccal Insulin Delivery via Hydrophobic Ion-Pairing Approach: In vitro and ex vivo Evaluation

Overall, the study has revealed a feasible alternative for injectable formulations, and thus, the HIP-nanocomplex strategy could serve as a platform for buccal delivery of peptide drugs (International Journal of Nanomedicine)