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Glycosmedia Weekly Diabetes News - 07/16/2021

Imatinib therapy for patients with recent-onset type 1 diabetes: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

A 26-week course of imatinib preserved β-cell function at 12 months in adults with recent-onset type 1 diabetes. Imatinib might offer a novel means to alter the course of type 1 diabetes (The Lancet Diabetes & Endocrinology)


Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes

In patients with CKD and type 2 diabetes, treatment with finerenone resulted in lower risks of CKD progression and cardiovascular events than placebo (NEJM)


Semaglutide’s Success Could Usher in a “New Dawn” for Obesity Treatment

Despite obesity specialists’ enthusiasm for the drug’s potential, they also described major barriers to uptake and accessibility. Those barriers, they say, are rooted in the sordid legacy of weight-loss drugs and outdated notions of obesity (JAMA)


Activation of Glucagon‐Like Peptide‐1 Receptor Ameliorates Cognitive Decline in Type 2 Diabetes Mellitus Through a Metabolism‐Independent Pathway

We concluded that liraglutide improves cognitive decline in patients with type 2 diabetes mellitus (Journal of the American Academy of Heart Association)


SGLT2 Inhibitors and the Clinical Implications of Associated Weight Loss in Type 2 Diabetes: A Narrative Review

The relationships between the magnitude of weight loss, improvement in glycemic control, and cardiorenal benefits with SGLT2i are still unclear (Diabetes Therapy)


Glucagon for hypoglycaemia treatment in type 1 diabetes

As novel and stable glucagon formulations are being approved and launched on the market, new possibilities for improved hypoglycaemia rescues and new treatment approaches emerge (Diabetes/Metabolism Research and Reviews)


Early versus late intensification of glucose-lowering therapy in patients with type 2 diabetes: results from the DISCOVER study

Late intensification of glucose-lowering therapy after first-line treatment failure reduces the likelihood of reaching recommended treatment goals (Diabetes Research and Clinical Practice)


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Comment on recently published papers written by the medical editors of Glycosmedia.

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