Glycosmedia Weekly Diabetes News - 08/20/2021

Cardiorenal outcomes with sodium/glucose cotransporter-2 inhibitors in patients with type 2 diabetes and low kidney risk: real world evidence

Our findings in the general population of patients with T2D demonstrates lower risk of cardiorenal outcomes associated with initiation of SGLT2i compared with oGLAs, including specifically in patients with low baseline kidney-risk (Cardiovascular Diabetology)

Association of maternal diabetes during pregnancy with high refractive error in offspring: a nationwide population-based cohort study

Our findings suggest that maternal diabetes during pregnancy is associated with an increased risk of high RE in offspring, in particular among those of mothers with diabetic complications (Diabetologia)

Completion of annual diabetes care processes and mortality: A cohort study using the National Diabetes Audit for England and Wales

People with diabetes who have fewer routine care processes have higher mortality (Diabetes, Obesity and Metabolism)

Heal Thyself: SGLT2 Inhibition Limits Regenerative Cell Exhaustion and Heals Damaged Vessels

Collectively, the study of Albiero et al. establishes novel mechanisms that clarify the critical role of BM-derived cellular subsets to directly enhance endothelial healing during diabetes (Diabetes)

Glycemic Variability and KIM-1–Induced Inflammation in the Diabetic Kidney

Recognition of DKD as an inflammatory disease linked by metabolic perturbations and immune responses is a central tenet that requires broader and deeper exploration (Diabetes)

Stratification of Type 2 Diabetes by Age of Diagnosis in the UK Biobank Reveals Subgroup-Specific Genetic Associations and Causal Risk Profiles

Collectively, our results indicate that stratification of T2D based on age of diagnosis reveals subgroup-specific genetics and causal determinants, supporting the hypothesis that the pathogenesis of T2D changes with increasing age (Diabetes)

Efficacy and safety of 28-day treatment with oral insulin (ORMD-0801) in patients with type 2 diabetes mellitus – A randomized placebo-controlled trial

In patients with T2DM, bedtime ORMD-0801 curbed increases in night-time glycemia, 24-hour glycemia and HbA1c, without increasing risk of hypoglycaemia, or safety events as compared to the control arm (Diabetes, Obesity and Metabolism)

Does Current Diabetes Technology Improve Metabolic Control? A Cross-Sectional Study on the Use of Insulin Pumps and Continuous Glucose Monitoring Devices in a Nationwide Pediatric Population

Despite the broad use of diabetes technology, as many as 61% of our pediatric cohort did not reach the HbA1c target recommended by the International Society for Pediatric and Adolescent Diabetes (Diabetes Therapy)

Differences in the roles of types 1 and 2 diabetes in the susceptibility to the risk of fracture: a systematic review and meta-analysis

This study found that T1DM caused an excess risk to all fractures, including fractures at the hip, upper arm, and ankle than T2DM (Diabetology & Metabolic Syndrome)

The risk of consequent nephropathy following initial weight loss in diabetic patients treated with sodium glucose cotransporter 2 inhibitors

A modest BW loss of 0–5% associated with SGLT2i treatment was associated with a favorable renal outcome. Caution should be taken for whom are underweight at baseline or have a pronounced BW loss ≥ 10.0% associated with SGLT2i treatment, which was associated with a worse renal outcome (Cardiovascular Diabetology)