Glycosmedia Weekly Diabetes News - 03/18/2022

Modeling Chronic Kidney Disease in Type 2 Diabetes Mellitus: A Systematic Literature Review of Models, Data Sources, and Derivation Cohorts

Modeling CKD in T2DM is an active research area, with a trend towards IPS models developed from non-Western data and single data sources, primarily recent outcomes trials of novel renoprotective treatments (Diabetes Therapy)

Relationship Between Muscle Cramps and Diabetic Retinopathy in Patients with Type 2 Diabetes

Muscle cramps occur frequently in diabetes and are correlated with diabetic retinopathy and albumin. Patients with PDR exhibited a higher frequency, severity, and longer duration relative to those with NPDR or without DR (Metabolic Syndrome and Obesity)

Screening Strategy for Islet Autoantibodies in Diabetes Patients of Different Ages

In patients stratified according to the cutoff age of 35 years, the optimal detection sequence should be GADA, IA-2A, and ZnT8A in younger patients and GADA, ZnT8A, and IA-2A in older patients, so as to reduce the screening cost while improving the detection rate. Particularly, the ZnT8A test is recommended in older patients to avoid a missed LAD diagnosis (Diabetes Technology and Therapeutics)

Why don’t children and young people engage with diabetes services?

This study included children and young people who were labelled ‘disengaged’ with their diabetes care. Interviews explored what they would like to change about current diabetes services (NIHR)

Automated Insulin Delivery with SGLT2i Combination Therapy in Type 1 Diabetes

In an 8-week outpatient study, addition of 5 mg daily empagliflozin to commercially available AID or PLGS systems significantly improved daytime glucose control in individuals with T1D, without increased hypoglycemia risk. However, the risk of ketosis and ketoacidosis remains (Diabetes Technology and Therapeutics)

Glycemic control and atrial fibrillation: an intricate relationship, yet under investigation

This review evaluates current anti-hyperglycemic treatment in the context of AF, and discusses AF-related decision-making in comorbid DM (Cardiovascular Diabetology)

Effect of glucagon-like peptide-1 receptor agonists on renal function: a meta-analysis of randomized controlled trials

Results of our meta-analysis revealed that GLP-1 RA treatment decreases urinary albumin excretion and albumin to creatinine ratio but it did not cause significant changes in creatinine levels and glomerular filtration rate (British Journal of Clinical Pharmacology)

Ambulatory Glucose Profile (AGP) Report in Daily Care of Patients with Diabetes: Practical Tips and Recommendations

Report and illustrate the essential components of an AGP review in a series of hypothetical, real-world, patient-centred case studies (Diabetes Therapy)

Association between triglyceride glucose index and carotid artery plaque in different glucose metabolic states in patients with coronary heart disease: a RCSCD-TCM study in China

The TyG index and CAP showed a significant association in CHD patients (Cardiovascular Diabetology)