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Glycosmedia Weekly Diabetes News - 06/03/2022

Fracture Risk of Sodium-Glucose Cotransporter-2 Inhibitors in Chronic Kidney Disease

In this cohort study of older adults, starting a SGLT2 inhibitor versus DPP-4 inhibitor was not associated with a higher risk of skeletal fracture, regardless of eGFR (Clinical Journal of the American Society of Nephrology)


Impact of short-term glycemic variability on risk of all-cause mortality in type 2 diabetes patients with well-controlled glucose profile by continuous glucose monitoring: a prospective cohort study

Greater %CV was associated with increased risk for all-cause mortality even among patients with seemingly well-controlled glucose status (Diabetes Research and Clinical Practice)


Associations of Maternal Gestational Diabetes Mellitus with Alterations in Cardiovascular System in Early Childhood

Our results provide evidence that maternal GDM is associated with offspring cardiovascular adaptations at preschool age. Further studies are needed to replicate our results and the long-term effect of these adaptations on later cardiovascular risks needs further investigation (Diabetes/Metabolism Research and Reviews)


The Association between Gut Microbiota and Insulin Therapy in Women with Gestational Diabetes Mellitus

Insulin therapy changed maternal gut microbiota composition, which could be transferable to their newborns (Canadian Journal of Diabetes)


Incidence and factors associated with acute kidney injury among children with type 1 diabetes hospitalized with diabetic ketoacidosis. A prospective study

AKI is common among T1DM children hospitalized with DKA. Younger age, low GCS at hospital admission and increased serum chloride level during DKA management were associated with increased risk for moderate to severe AKI development (Pediatric Diabetes)


Additional Insulin Dosing for Fat and Protein in Children with Type 1 Diabetes using Multiple Daily Injections

We found no benefit in giving additional insulin as a split dose for HFHP meals in children using MDI, mild hypoglycaemia was common. Future studies would benefit from refinement of the insulin dose algorithm (Pediatric Diabetes)


Roles of FoxM1-driven basal β-cell proliferation in maintenance of β-cell mass and glucose tolerance during adulthood

Basal low-level proliferation of β-cells during adulthood is important for maintaining sufficient β-cell mass and good glucose tolerance and β-cell FoxM1 underlies this mechanism. Preserving β-cell FoxM1 activity may prevent impairment of glucose tolerance with advancing age (Journal of Diabetes Investigation)


Association of ambulatory blood pressure with coronary microvascular and cardiac dysfunction in asymptomatic type 2 diabetes

24-h ambulatory systolic BP, but not office BP, is independently associated with cardiac remodeling, coronary microvascular dysfunction, and diastolic dysfunction among asymptomatic individuals with T2D (Cardiovascular Diabetology)


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