We've seen a ton of big-time young running backs enter the NFL in recent years, and Derrius Guice looked like he was going to be part of another talented rookie class. That will have to wait until next year, unfortunately, as Guice went down with a knee injury in Thursday's preseason opener, and it will cost him his entire rookie season. We break down the Fantasy ramifications in Washington and beyond.

With Derrius Guice out for the season, will anyone step up in Washington's backfield? Dave Richard isn't getting excited.

With Guice out, what should you expect from the rest of the team? Heath Cummings investigates.

Want to see how the RB projections shake out with Guice out of the picture? Heath Cummings updates them.

Dave Richard updates his rookie RB breakdown in light of Guice's injury. Which young back moves up the ranks?