Is there really a Paxlovid COVID-19 rebound?

Reports of rebound COVID-19 infections—testing positive, then negative, then positive again—among people taking the antiviral Paxlovid have started to mount. Which raises the question: what’s the likelihood of a similar rebound if you don’t take Paxlovid?

That’s what a new study set out to understand. It’s not the definitive answer about how much rebound is associated with a course of Paxlovid treatment—which involves taking pills over five days—but it offers some useful insight for those making the decision of whether or not to take the drug. Here’s what the study found:

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