Raheem Mostert, step right up! 

Mostert is Jamey Eisenberg's pick for Start of the Week in his first Start 'Em & Sit 'Em column of the season, and it's not exactly hard to see why. Mostert is a very efficient runner with the ability to break off a long play any time, and the only real knocks against him as a Fantasy option are injury risk and the possibility that Trey Sermon may overtake him as the lead back down the road. But neither of those should be a concern in Week 1, especially not against a soft Lions defense. 

Mostert is Jamey's favorite play this week, and you can read more about why he chose to feature him in the Start 'Em & Sit 'Em column right here, along with his picks for every other position in Week 1. In this afternoon's special newsletter -- and you can expect one every Tuesday evening -- we're highlighting Jamey's top picks for the week at QB, RB, and WR as well.

Tomorrow morning, you'll get your typical Fantasy Football Today newsletter, featuring Dave Richard's Start/Sit picks, some bold predictions from the entire FFT staff, and a preview of Thursday night's season opener between the Cowboys and Buccaneers. 

But for now, here's who Jamey is starting and sitting this week: 

Start 'Em: Jalen Hurts a and Ryan Tannehill

"The Falcons defense was bad against opposing quarterbacks last season, and things might not improve much this year. Hurts enters this season with a revamped offensive line and receiving corps, and he has the chance for a strong debut against Atlanta. He has top-five upside for Week 1, and hopefully we see plenty of running from Hurts this week -- and beyond."

Sit 'Em: Joe Burrow and Jameis Winston

"I'm excited for Winston as the starter for the Saints, but I'd also like to wait and see how he does before starting him in a one-quarterback league. For starters, he doesn't have Michael Thomas (ankle) for at least the first five games, which is a downgrade. And we don't know how Sean Payton will use Taysom Hill in tandem with Winston to take him off the field. This isn't an easy matchup against the Packers, and the Saints lost their home-field advantage with the game moved to Jacksonville because of Hurricane Ida. Give Winston time, if you can, before making him a Fantasy starter."

Start 'Em: Gus Edwards and Chase Edmonds

"Edwards takes over as the starter for the injured J.K. Dobbins (ACL), and he should have the chance for a big Week 1 against the Raiders. Las Vegas was among the worst teams against opposing running backs last season, and the Raiders run defense could still be a problem again this year. We'll see how Baltimore uses backup running back Ty'Son Williams this week (Le'Veon Bell was signed to the practice squad for now), and he should be considered a sleeper for this matchup as well. But Edwards is a must-start running back, even in PPR, given his opportunity to lead the Ravens in carries in a plus matchup."

Sit 'Em: Josh Jacobs and D'Andre Swift

"Jacobs will hopefully get off to a fast start in this game, but he typically struggles when the Raiders are losing. And we'll see how Las Vegas plans to use Jacobs in tandem with Kenyan Drake. The Ravens run defense should make it tough on the new offensive line for the Raiders, and I would only use Jacobs as a flex option this week at best, with his value higher in non-PPR leagues."

Start 'Em: Robby Anderson and Brandon Aiyuk

"Anderson is reunited with Sam Darnold, and the two will take on their former team this week at home. Anderson should have the chance for a strong first game, and he started last season on a high note for the Panthers with at least 17 PPR points in four of his first five games. While Christian McCaffrey is back, and the Panthers added Terrace Marshall to replace Curtis Samuel, look for Darnold to feature Anderson quite a bit this week -- and all year."

Sit 'Em: Kenny Golladay and Marquez Callaway

"Callaway is now the No. 1 receiver for the Saints until Michael Thomas (ankle) returns, but that means he's going to face a tough matchup from the Packers and cornerbacks Jaire Alexander and Kevin King. We'll find out quickly if Callaway is ready to handle that type of attention, but he excelled in the preseason in matchups against Ravens cornerbacks Marlon Humphrey and Marcus Peters and Jacksonville's Shaquill Griffin. I'd use Callaway as a No. 3 Fantasy receiver this week, but I don't have high expectations in his first real game as the No. 1 guy."

Start 'Em: Tyler Higbee

"Higbee missed last year's game against the Bears in Week 7, but Gerald Everett had a solid performance with four catches for 28 yards and a touchdown on five targets. Higbee has done well in his career when Everett hasn't played, and Everett is now in Seattle. It helps Higbee that the Bears were No. 2 in Fantasy points allowed to tight ends last year."

Sit 'Em: Blake Jarwin

"I'm hopeful that Jarwin will distance himself from Dalton Schultz to be the lead tight end in Dallas, but both could share the No. 1 role all season and for Week 1 at Tampa Bay. Even though the Buccaneers were No. 10 in Fantasy points allowed to tight ends, this is a matchup I would prefer to avoid. Keep an eye on Jarwin because he still has sleeper appeal for the season, but leave him on your bench this week."

Start 'Em: Broncos vs. Giants

"Denver gets to face Daniel Jones, who has 39 turnovers in 27 career games. Saquon Barkley (knee) and Kenny Golladay (hamstring) might not be at 100 percent. The offensive line for the Giants is still a concern as well. I like the Broncos DST as a top-five Fantasy option for Week 1. And Denver also faces Jacksonville in Week 2 and the Jets in Week 3, which should also be favorable matchups."

Sit 'Em: Seahawks

"The Seahawks offense will be tough to slow down, and Seattle was able to get left tackle Duane Brown signed and ready for Week 1, shoring up the offensive line. The Colts DST will have plenty of positive moments this year, but the early-season schedule of Seattle, the Rams, Tennessee, Miami and Baltimore could be tough. I would avoid the Colts DST for most of those matchups."