If you've been following this newsletter, you know I've been advocating for Matthew Stafford as a starting Fantasy QB for the past few weeks. In Week 6, I've got some company. 

Jamey Eisenberg has picked Stafford as his Start of the Week for this week's matchup against the Cardinals , and it's not hard to see why. Of course, you might need to look past his middling QB17 ranking entering Week 6 to see it, because Stafford has had some trouble finishing off drives, leading to just one multi-touchdown game so far. Of course, that game happened to be in Week 5, when he happened to get Cooper Kupp, who happens to be maybe the best wide receiver in the NFL, back from injury. 

The Rams have been one of the most pass-heavy teams in the league, and Stafford has been aggressive throwing the ball. After dipping down to 6.7 air yards per attempt last season, he's back up to 8.4, right where he was in 2021, a good sign for this offense's chances of unlocked upside in any given week. Stafford is healthy and pushing the ball aggressively down the field, and now he's got his best weapon back, in addition to the breakout star of the 2023 season, Puka Nacua. The 290.2 passing yards per game are Stafford's most since 2019, and with Kupp back, the touchdowns should be more plentiful moving forward, too. 

You can read more about why Jamey expects big things from Stafford this week, along with the rest of his Start 'Em & Sit 'Em calls here, and the rest of today's newsletter has start/sit calls for every position to help you make the best decisions possible. Tomorrow, we'll have our preview of every game on the Week 6 schedule, with more start and sit calls, the latest injury news, and more: 

• Week 6 Position Previews: QB | RB |  WR |  TE
• Jamey, Dave, Heath's Rankings
• My Week 6 Rankings:  QB |  RB | WR | TE
  

Start 'Em: Joe Burrow and Trevor Lawrence

"I wrote in Start 'Em & Sit 'Em last week that I needed to see Burrow look like Burrow again before we could start him with confidence. Well, he's back, and hopefully the best is yet to come. Burrow lit up the Cardinals for 317 passing yards, three touchdowns and one interception in Week 5, with all three scores going to Ja'Marr Chase. For the first time this season, Burrow didn't seem to be bothered by the calf he originally injured at the beginning of training camp, and he should have another quality outing against Seattle on Sunday. Two of the past three quarterbacks to face the Seahawks (Jared Goff and Andy Dalton) have scored at least 27.5 Fantasy points."

Sit 'Em: C.J. Stroud and Deshaun Watson

"The Falcons cooled Stroud off in Week 5, holding the rookie to 16.2 Fantasy points, which snapped a three-game streak of him scoring at least 24.6 points. I expect the Saints to also keep Stroud in check in Week 6. Safety Marcus Maye returns to the New Orleans secondary after his three-game suspension, and we'll see if the Saints can be the first team to get an interception off Stroud. He also hasn't been sacked in three games in a row. The key will be if Stroud gets a second touchdown or not if he remains without a turnover (he hasn't fumbled since Week 2), and rookie receiver Nathaniel Dell (concussion) could be out in Week 6. I would only start Stroud in Superflex and two-quarterback leagues in this matchup."

Start 'Em: Isiah Pacheco and Alexander Mattison

"Pacheco has been great so far this season, scoring at least 13.4 PPR points in three games in a row, and he should have the chance for another huge outing in Week 6 against Denver. The Broncos are No. 1 in most Fantasy points allowed to opposing running backs, and Week 5's Start of the Week Breece Hall became the fifth running back in the past four games to score at least 22.2 PPR points against Denver, joining Brian Robinson Jr., De'Von Achane, Raheem Mostert and Khalil Herbert. Jerick McKinnon and possibly Clyde Edwards-Helaire also have sleeper appeal given this matchup, but Pacheco is worth starting as a No. 1 Fantasy running back in all leagues."

Sit 'Em: Jerome Ford and Dameon Pierce

"Be patient with Ford, because after Week 6 we might have a must-start running back in all leagues. Starting in Week 7, Ford gets to face Indianapolis, Seattle and Arizona, and those are all favorable matchups after he's dealt with Tennessee, Baltimore and now San Francisco in Week 6 since he took over for the injured Nick Chubb (knee). While Ford did score 19.1 PPR points against the Titans with two touchdowns, he had just 41 total yards in that game, and he followed that up with 45 total yards against the Ravens. We'll see if Deshaun Watson (shoulder) plays against the 49ers, but San Francisco is a brutal matchup since only Kyren Williams in Week 2 has scored more than 10.8 PPR points against this defense. Ford should be considered a flex at best in most leagues for Week 6."

Start 'Em: Jakobi Meyers and Jordan Addison

"Justin Jefferson (hamstring) is on IR, which should allow Addison and K.J. Osborn the chance for a big game in Week 6 at Chicago. Osborn is more of a sleeper as a No. 3 Fantasy receiver, but Addison should be a standout No. 2 Fantasy receiver in all leagues. He already has three touchdowns in five games this season with Jefferson on the field, and in three games with at least six targets (Week 1, Week 3 and Week 5), Addison is averaging 15.2 PPR points per game, with two touchdowns. The Bears have allowed three receivers to score at least 18.5 PPR points this season ( Romeo Doubs, Mike Evans and Curtis Samuel ), and Addison could add his name to that list in Week 6."

Sit 'Em: Amari Cooper and Courtland Sutton

"We usually like Cooper at home no matter what, but he clearly needs quality quarterback play in a tough matchup to succeed. We saw that in Week 4 against Baltimore when Dorian Thompson-Robinson started in place of Deshaun Watson (shoulder), and Cooper was held to one catch for 16 yards on six targets. Fast forward to Week 6 after Cleveland's bye, and Watson is still hurt, which means he'll either play at less than 100 percent or sit. This time, P.J. Walker would start for the Browns if Watson is out, but Cooper still has a tough matchup against the 49ers. I'd only start Cooper in three-receiver leagues in Week 6."

Start 'Em: Cole Kmet

"Is Kmet getting hot because of Justin Fields, or is Fields getting hot because of Kmet? It's a nice problem to try and solve since both have been great for the past two games. Against Denver and Washington, Kmet has 12 catches for 127 yards and three touchdowns on 14 targets, and he's become a go-to option for Fields. Kmet has scored at least 13 PPR points in two of his past three meetings with the Vikings, and Minnesota has allowed three tight ends (Dallas Goedert in Week 2, Gerald Everett in Week 3 and Travis Kelce in Week 5) to catch at least six passes this season."

Sit 'Em: David Njoku

"Njoku actually had his best performance of the season in Week 4 against Baltimore without Deshaun Watson (shoulder) and playing despite suffering burns to his face and hand prior to the game. He caught six passes for 46 yards on seven targets, and his 10.6 PPR points were a season-high. We'll see if Watson is able to play against San Francisco in Week 6, but I would try to avoid Njoku in most leagues for this week. The 49ers have allowed one touchdown to a tight end this year, which was Pat Freiermuth in Week 1, and Zach Ertz in Week 4 is the lone tight end with more than 7.3 PPR points against this defense."

Start 'Em: Dolphins vs. CAR

"The Dolphins defense just had a season-high seven sacks in Week 5 against the Giants, and Miami has held three of its past four opponents to 17 points or less. The Dolphins only have five turnovers on the season (two interceptions and three fumble recoveries), but that could change for the better in Week 6 against the Panthers . Carolina has four interceptions and four fumbles this year, and the Panthers have scored 17 points or less in three of four starts for Bryce Young. The Dolphins DST has top-five upside in Week 6 at home."

Sit 'Em: Browns vs. SF

"The Browns defense has played great this season, and Cleveland has held three of four opponents to 14 points or less. The Browns have eight sacks in their past two games against the Titans and Ravens, and Cleveland's defense should be rested coming off a bye. But the Browns DST will be tested against the 49ers, who have scored at least 30 points in every game this season. Brock Purdy has yet to throw an interception, and the 49ers have allowed just eight sacks this year. I don't expect the Browns DST to slow down the 49ers in Week 6, even at home, so you should find an alternate DST for this matchup."