The Wall Street Journal: Obama Picks Merrick Garland For Supreme Court, Setting Off High-Stakes Fight With Senate
President Barack Obama nominated federal appeals court judge Merrick Garland to the Supreme Court, unleashing a showdown with the Republican-controlled Senate over the court’s first vacancy in six years. Wednesday’s nomination of Judge Garland, a veteran jurist with a reputation for consensus-building, landed in the middle of a heated election battle and at a time when the nation’s highest court is bitterly divided on hot-button issues that include abortion, campaign finance and gun rights. (Lee and Peterson, 3/16)

Politico: Planned Parenthood Chief Urges Senate To Hold Hearing On Garland
Planned Parenthood President Cecile Richards headed into the West Wing right after Merrick Garland’s Supreme Court nomination was announced — and she seems to like what she heard. "Judge Garland seems like a responsible and qualified nominee,” Richards said in a statement Wednesday afternoon, throwing her support behind giving the D.C. Circuit Court of Appeals chief judge a hearing. Abortion rights, of course, are the perennial major issue in Supreme Court politics — and on the frontburner for the Supreme Court this year, with a big case challenging Texas state restrictions in front of the justices. (Dovere, 3/16)

Modern Healthcare: SCOTUS Pick Has History In Healthcare-Related Cases
Lawmakers will almost certainly spend coming months digging through Garland's judicial record to see where he stands politically. As chief justice of the U.S. Court of Appeals in Washington, Garland, who is viewed as moderate, has been involved in a number of healthcare-related cases, sometimes siding with hospitals and other times with HHS. Garland was part of a three-judge panel in May that partially sided with hospitals in a case over Medicare outlier payments. ... Also, in December, Garland was part of a three-judge panel that sided with HHS in a case brought by Fayetteville City Hospital in Arkansas, which was reportedly closed by Washington Regional Medical Center in 2012. ... A few years earlier, in 2011, Garland was part of a three-judge panel that sided with Beverly Hospital in Massachusetts after it challenged reimbursements it received from HHS for services it provided to low-income beneficiaries. ... Garland's court has also dealt with several challenges to the Affordable Care Act. (Schencker, 3/16)

Politico: Garland’s Lack Of Standout Opinions A Boon In Confirmation Fight
Supreme Court nominee Merrick Garland’s nearly two-decade tenure as a judge on the D.C. Circuit holds few seminal opinions that capture his legal philosophy—and, for those rooting for his confirmation, that may be a good thing. ... A former prosecutor, Garland often split with his liberal colleagues on criminal justice issues, while broadly approving of federal government regulatory actions in areas like health and the environment. On the First Amendment, he has leaned towards free speech rights, while his stances in other areas like abortion rights and church-state issues are uncharted. (Gerstein, 3/16)

The New York Times: Bill To Stop States Requiring Labeling Of GMO Foods Fails
A bill that would prevent states from requiring food labels to note the presence of genetically engineered ingredients failed to pass the Senate on Wednesday. Republicans in Congress, led in the Senate by Pat Roberts of Kansas, had been scrambling to come up with a bill that would head off mandatory labeling in Vermont, which goes into effect on July 1. Many food companies have already gotten approval for the language they will use on packaging there, but they worry that other states will pass similar laws, creating a patchwork of requirements that will add to the cost of compliance. (Strom, 3/16)

The Associated Press: Senate Effort To Block Food Labeling Of Modified Food Stalls
The procedural vote is a setback for many big players in the food industry who had lobbied to block Vermont’s law. The industry argues that genetically modified organisms, or GMOs, are safe and the labels could be costly for agriculture, food companies and consumers. Congressional Republicans have opposed a patchwork of state laws and worked to find a solution on the issue before Vermont’s law kicks in. The food industry says about 75 percent to 80 percent of foods contain genetically modified ingredients. (3/16)

CQ Healthbeat: Senate Unable to Advance GMO Bill To Limit State Labeling
A closely divided Senate may revisit legislation to bar states from imposing mandatory labeling of genetically modified foods after lawmakers on Wednesday rejected a procedural move to limit debate and advance the measure. The amendment attached to an unrelated bill (S 764) sought to block states from writing mandatory labeling laws and establish a federal voluntary labeling process created and administered by the Agriculture Department. (Ferguson, 3/16)

The Associated Press: Vermont Governor Hails Senate Defeat Of GMO Foods Bill
Vermont's law requiring most genetically modified food to be labeled as such remains on schedule to take effect July 1, after the U.S. Senate on Wednesday voted not to advance a bill that would have blocked such state laws. On a 48-49 procedural vote — short of the 60 votes needed for passage — the Senate decided not to go ahead with legislation similar to a bill passed by the U.S. House last year. The decision was hailed by U.S. Sen. Patrick Leahy and Gov. Peter Shumlin, both Democrats, and independent U.S. Sen. Bernie Sanders. It was sharply criticized by industry groups, which vowed to continue fighting for the legislation and are also seeking to have Vermont's law overturned in Federal court. (Gram, 3/16)

The Associated Press: Governor, EPA Chief Agree: Michigan Agency Failed Flint
The Michigan Department of Environmental Quality repeatedly gave assurances that water from the Flint River was safe, when in reality it had dangerous levels of lead, Michigan Gov. Rick Snyder says. Snyder tells Congress that he did not learn that Flint's water was contaminated until Oct. 1, 2015 — nearly 18 months after the city began drawing its water from the Flint River in April 2014 to save money. Snyder said he took immediate action, reconnecting the city with Detroit's water supply and distributing water filters and testing residents — especially children — for elevated lead levels. (3/17)

Detroit Free Press: Snyder Disappointed With Federal Denial Of Funding For Flint
Gov. Rick Snyder said Wednesday he's disappointed the federal government has rejected his appeal of an earlier denial of certain funding requests to assist the state in addressing the Flint drinking water crisis. Snyder, in a March 3 letter to the Federal Emergency Management Agency, had requested funding under programs related to emergency protective measures and the Individuals and Households Program. (Egan, 3/16)

Meanwhile, media outlets report on lead dangers in New York and Colorado —

The Wall Street Journal: Federal Prosecutors Probe Lead Problems In NYC Public Housing
Federal prosecutors in Manhattan are investigating health and safety conditions, including lead problems, in New York City’s public-housing system, according to court documents and city officials. Prosecutors in U.S. Attorney Preet Bharara’s office are investigating whether the New York City Housing Authority, the largest public-housing agency in the country, made false claims for payment to the federal government related to safety conditions at city housing complexes, according to court filings. The investigation began last fall, court records show. (O'Brien, 3/16)

The New York Times: U.S. Investigating Elevated Blood Lead Levels In New York’s Public Housing
Federal prosecutors in Manhattan are conducting a sweeping investigation of environmental health and safety conditions, including cases of elevated blood lead levels, in public housing and homeless shelters and the possibility that the New York City housing and homeless agencies filed false claims to federal housing officials for payment related to the conditions. (Navarro and Rashbaum, 3/16)

USA Today: Colo. Town's Tests Reveal Lead In Water Of Older Homes
Standing glumly behind the screen door of the brick house she has called home since 1971, Mary Schell shares the bad news: "We have it." "It" is confirmation that the water in her home contains high levels of lead. Schell and her husband tested their water in the fall after town officials discovered in October that 11 homes in their neighborhood had high levels. A subsequent round of testing in December found six homes exceeding federal limits. (Hughes, 3/16)

The Associated Press: Deficit-Slashing Plan Advances Through House Panel
A key House panel on Wednesday approved a GOP plan to eliminate the federal budget deficit without tax increases demanded by Democrats, relying on sharp cuts to federal health care programs, government aid to the poor, and hundreds of domestic programs supported by lawmakers in both parties. The 20-16 Budget Committee vote could be the high point for the GOP blueprint, which is short of the majority votes needed to advance through the GOP-controlled House. Two tea party Republicans defected on the otherwise party-line vote. (3/16)

The Connecticut Mirror: Murphy Mental Health Bill Wins Big Bipartisan Support – After Some Changes
A key committee on Wednesday voted unanimously to send a mental health bill sponsored by Sen. Chris Murphy to the Senate floor, but not until certain provisions were dropped. The Mental Health Reform Act, which is co-sponsored by Sen. Bill Cassidy, R-La., would establish a new a new assistant secretary for mental health and substance abuse and establish a new grant program for early intervention aimed at helping children and young adults. (Radelat, 3/16)

Reuters: Senate Advances Bill To Aid Drug-Dependent Newborns
A bipartisan bill designed to improve the health and safety of babies born to mothers who used heroin or other opioids during pregnancy was approved by a U.S. Senate committee on Wednesday. The bill, which will now move to the Senate floor, was prompted by a Reuters investigation last year. Reuters found 110 cases of children who were exposed to opioids while in the womb and who later died preventable deaths at home. No more than nine states comply with a 2003 law that calls on hospitals to alert social workers whenever a baby is born dependent on drugs, Reuters found. (Shiffman and Wilson, 3/16)

Modern Healthcare: Conservative Lawmakers, Aetna CEO Suggest Advantage Plans Could Help Save Medicare
Lawmakers, health policy experts and the chief executive of one of the nation's largest insurers believe Medicare Advantage could help keep the Medicare program solvent. On Wednesday, the House Ways and Means Committee's Health Subcommittee held a hearing on Medicare's future. The Medicare board of trustees said in its most recent annual report that Medicare will be able to cover its costs until 2030, but suggested congressional action to strengthen the program's future. (Muchmore and Herman, 3/16)

CQ Healthbeat: House Appropriators Push Back On Mandatory NIH Funding
House appropriators at a hearing on the National Institutes of Health budget flatly rejected the Obama administration’s proposal to use mandatory spending, rather than discretionary appropriations, to fund part of the biomedical research agency. President Barack Obama’s proposed fiscal 2017 budget designates $33.1 billion for NIH, including new funds for the “moonshot” initiative to cure cancer being spearheaded by Vice President Joseph R. Biden Jr. The fiscal 2016 omnibus boosted the agency’s budget by $2 billion, bringing it to $32.1 billion. (Zanona, 3/15)

The Wall Street Journal: Some Co-Ops Under Health Law Still Have Tepid Enrollment
Four of the 11 remaining health cooperatives set up under the Affordable Care Act are still seeing tepid enrollment, according to a report by federal investigators, in another sign such insurance startups are on shaky footing despite more than $1 billion in federal loans. The cooperatives were launched under the health law to provide affordable insurance and infuse competition into the market. Twelve of the 23 co-ops that got off the ground have closed as a result of financial troubles. The Obama administration is seeking to recoup about $1.2 billion in federal loans to the co-ops that have closed. (Armour, 3/16)

The Boston Globe: To Keep Health Care Subsidies, Residents Must File Federal Tax Returns
State officials and consumer advocates are reminding Massachusetts residents with subsidized health insurance coverage to file their tax returns before April 19 -- or risk losing their federal tax credits. For the first time this year, 174,000 people in Massachusetts who receive tax credits to offset the cost of their health insurance must file a tax form to prove they were eligible for the credits. Those who don’t file could be forced to pay back their tax credits or lose eligibility for credits in future years. Tax credits are available to help individuals and families with low or moderate income pay for health coverage. (Dayal McCluskey, 3/16)

NPR: Medical Debt Rains Pain On Families, Even In The Sunshine State
Health insurance is no guarantee against financial hardship, according to a national poll by NPR, the Robert Wood Johnson Foundation and the Harvard T. H. Chan School of Public Health. "People are financially overwhelmed in lives that are working OK — they have financing for everything else in their life but they can't deal with this large medical bill," says Robert Blendon, a professor of health policy and political analysis at the Harvard Chan School. (Mack, 3/17)

NPR/ProPublica: Drug-Company Payments Mirror Doctors' Brand-Name Prescribing
Doctors have long disputed the accusation that the payments they receive from pharmaceutical companies have any relationship to how they prescribe drugs. There's been little evidence to settle the matter, until now. A new ProPublica analysis has found that doctors who receive payments from the medical industry do indeed prescribe drugs differently on average than their colleagues who don't. And the more money they receive, the more brand-name medications they tend to prescribe. (Ornstein, Jones and Tiga, 3/17)

In other news, the FDA says it's going to prioritize generic drug applications —

Marketplace: FDA Takes Step To Improve Generic Drug Competition
We’d all be paying a whole lot more if it wasn’t for generics, which amounts to as much as 85% of what we take. The Food and Drug Administration recently said it’s going to prioritize any generic drug application when there’s currently just one manufacturer. (Gorenstein, 3/15)

The Wall Street Journal: Amgen’s Patents On Cholesterol Drug Declared Valid By Jury
A jury declared valid two Amgen Inc. patents linked to the company’s recently approved cholesterol-lowering drug, delivering a setback to Regeneron Pharmaceuticals Inc. and Sanofi, makers of a rival drug. Regeneron and Sanofi, in a prepared statement, said they “strongly disagree” with the verdict by the Delaware jury and that they plan to appeal. (Stynes, 3/16)

Bloomberg: Amgen Bests Regeneron In Patent Fight Over Cholesterol Drugs
Amgen Inc. won a legal victory over Regeneron Pharmaceuticals Inc. in an intellectual property battle over their cholesterol-reducing drugs. Regeneron said it would appeal the decision. A federal jury in Wilmington, Delaware, rejected Regeneron’s challenges and ruled in Amgen’s favor that two of its patents on its drug, Repatha, were valid, according to a statement Wednesday from Regeneron and its partner Sanofi. Amgen rose less than 1 percent to $143.97 at 3:32 p.m. in New York. Regeneron rose less than 1 percent to $369.04. (Bloombfield and Milford, 3/16)

Reuters: UK Cost Agency Rejects Amgen's Virus-Based Cancer Drug
A first-in-class melanoma drug from Amgen based on a tumor-killing virus has been deemed not worth using on Britain's state health service by the country's cost-effectiveness agency NICE. The National Institute for Health and Care Excellence said on Wednesday there was not enough evidence to be able to say whether Imlygic, also known as talimogene laherparepvec or "T-Vec", was as clinically effective as other drugs for the deadly skin cancer. (3/16)

The Wall Street Journal: Novartis Heart-Failure Pill Hits Hurdles With Doctors
In July, Novartis AG won regulatory approval for a new heart-failure pill that it called “one of the most remarkable drugs in cardiovascular medicine in the last several decades.” Since then, it has faced a problem: getting doctors to prescribe it. The drug, called Entresto, had $21 million in sales in the six months following its launch, a fraction of the $126 million expected by industry analysts. It also missed the company’s undisclosed internal forecasts, said David Epstein, head of pharmaceuticals at Novartis. (Roland, 3/16)

In other pharmaceutical news —

Bloomberg: The Trouble With Female Libido Pill Is A Symptom of Valeant Woes
Valeant Pharmaceuticals International Inc.’s struggles to ramp up sales of its new female libido pill offer a window into the drugmaker’s woes. The mail-order pharmacy that could have helped distribute the drug is now out of the picture following a scandal that forced Valeant to sever the relationship in October. Insurers are denying or limiting coverage for the daily pill, called Addyi, and large pharmaceuticals benefit managers are blocking it. The result: Many prescriptions written by doctors aren’t getting filled. (Koons, 3/17)

The Wall Street Journal: GlaxoSmithKline Says Andrew Witty To Retire As CEO
Pharmaceutical giant GlaxoSmithKline PLC on Thursday said Andrew Witty would retire as chief executive in March 2017 after roughly 10 years as CEO of the company. Glaxo said it would begin a formal search for a successor, and consider both internal and external candidates for the role. (Kent and Walker, 3/17)

Reuters: Vectura To Buy SkyePharma For 620M As UK Biotech Consolidates
Respiratory drug specialist Vectura has agreed to buy rival SkyePharma (SKP.L) for 441 million pounds ($621 million), in a notable piece of consolidation among Britain's universe of small biotech companies. The tie-up will create a lung disease group with expertise across different inhaler technologies and a combined market value of more than 1 billion pounds, which should attract a wider range of institutional investors. (Hirschler, 3/16)

Reuters: McKesson Cuts 1,600 Jobs To Trim Costs
U.S. drug distributor McKesson Corp (MCK.N) said on Wednesday it cut 1,600 jobs, or about 4 percent of its U.S. workforce, to slash costs after the company lost some key customers. McKesson said in January it would review its cost structure and decided that "reductions to our workforce would be necessary to align our cost structure with our business needs," the company said in an e-mailed statement. (3/16)

The New York Times: Patients In Pain, And A Doctor Who Must Limit Drugs
Susan Kubicka-Welander, a short-order cook, went to her pain checkup appointment straight from the lunch-rush shift. “We were really busy,” she told Dr. Robert L. Wergin, trying to smile through deeply etched lines of exhaustion. “Thursdays, it’s Philly cheesesteaks.” Her back ached from a compression fracture; a shattered elbow was still mending; her left-hip sciatica was screaming louder than usual. She takes a lot of medication for chronic pain, but today it was just not enough. Yet rather than increasing her dose, Dr. Wergin was tapering her down. “Susan, we’ve got to get you to five pills a day,” he said gently. She winced. (Hoffman, 3/16)

Meanwhile, a poll gauges Americans' reactions to the epidemic and the new CDC guidelines —

STAT: 1 In 3 Americans Blame Doctors For National Opioid Epidemic, Harvard Poll Finds
Americans broadly support new Obama administration guidelines urging physicians to prescribe fewer powerful painkillers, according to the latest STAT-Harvard poll. They blame doctors for the nation’s epidemic of opioid addiction about as much as they hold individuals responsible for abusing the drugs. (Scott, 3/16)

The Washington Post: Our Alarmingly Polluted Environment Is Killing 12.6 Million Each Year, WHO Warns
The World Health Organization has put a number on the people estimated to have died as a result of living or working in an unhealthy environment and it's big -- 12.6 million. That number represents one in four of all deaths globally and underscores the devastating impact of the chemicals and waste we've been putting into the air, water and earth since the end of World War II. The WHO said deaths due to non-communicable diseases -- which include heart disease and cancer and are related to exposure to pollution -- now make up 8.2 million or nearly two-thirds of the total deaths. Deaths from infectious diseases -- such as malaria and diarrhea -- due to unsafe water and lack of sanitation represent one-third and are on the decline. (Cha, 3/16)

Reuters: Air Pollution Not Just Bad For Your Lungs
Exposure to air pollution for just a month or two may still be enough to increase the risk of developing diabetes, especially for obese people, a recent U.S. study suggests. Researchers studied more than 1,000 Mexican-Americans living in southern California and found short-term exposure to contaminated air was linked to an increased risk of high cholesterol and impaired processing of blood sugar – risk factors for diabetes. (Rapaport, 3/16)

The Washington Post: Scientists Expose Vaccine Volunteers To Dengue Virus And Find 100 Percent Were Protected
Scientists reported on Wednesday that they think they have found the "final puzzle piece" for a dengue vaccine that might, at last, be able to stop the deadly mosquito-borne virus that has infected billions since the early 19th century. The experimental vaccine, developed by the National Institutes of Health, was tested in a small, randomized, double-blind trial on 41 healthy volunteers. Each participant received either a single shot of an experimental vaccine or a placebo and were then infected with a mild form of the virus six months later. All of the 20 people in the placebo group came down with rashes, low white blood cell count and other symptoms of the disease, while none of the 21 vaccinated volunteers became sick and did not have evidence of infection in their blood. (Cha, 3/16)

In other news, Ohio begins testing for Zika in its own Department of Health to cut back on frustrating federal wait times —

The Columbus Dispatch: Ohio Department Of Health Now Testing For Zika Virus In Its Lab
People suspected of carrying the Zika virus can wait weeks for test results from a federal lab. The wait can be nerve-racking for patients, especially pregnant women, and frustrating for local health officials who can't take precautions to stem potential spreading. (Somerson, 3/16)

The Cleveland Plain Dealer: Ohio Health Department Starts Zika Virus Testing
The Ohio Department of Health can now test blood samples of people who show symptoms of Zika virus to detect the mosquito-borne illness. "By conducting our own initial Zika virus testing on patients within seven days of symptom onset, we can significantly speed up initial test results for patients who are anxiously waiting on them," ODH Medical Director Dr. Mary DiOrio said in a news release. (Zeltner, 3/16)

The Associated Press: Law Enforcement Opposes Part Of Needle Exchange Bill
State and local law enforcement officials spoke out Tuesday against part of a bill aimed at making it easier for drug addicts to exchange dirty needles for clean ones, but they oppose the measure for different reasons. Under current law, hypodermic needles and syringes can be dispensed only by pharmacists, and possessing a used syringe with heroin residue on it is a felony. But a bill before the House Criminal Justice and Public Safety Committee would legalize residual amounts of heroin on used syringes and would allow nonprofit and community groups to create needle exchange programs. (Ramer, 3/16)

The Associated Press: Lawmaker: 'Aid In Dying' Bill Gives Patients Alternative
Terminally ill patients with only six months left to live could be prescribed life-ending medication under a bill moving through the Minnesota Legislature. The Minnesota Compassionate Care Act would make the state the sixth in the nation to enact so-called "Right to Die" legislation. Hundreds of people packed into a Senate hearing room on Wednesday afternoon with many opponents donning red shirts and stickers and bill proponents dressed in bright yellow. (3/16)

Iowa Public Radio: State Senators Frustrated With Lack Of Medicaid Info From DHS
Medicaid officials from the Iowa Department of Human Services shared with state senators on Wednesday how the department plans to make sure Medicaid recipients are safe and receive necessary services, once the Iowa's Medicaid system is privatized on April 1. (Boden, 3/16)

The Associated Press: NY Caregivers For The Disabled Urge Funding For Higher Wage
About 75 disabled New Yorkers and their caregivers are lobbying legislators to cover higher reimbursements should they enact a $15 state minimum wage. Gov. Andrew Cuomo and the Assembly are pushing to raise the wage over three years in the New York City area and five years statewide. (3/17)

The Associated Press: Gov. Snyder Signs Law Extending Health Insurance Tax
Michigan's tax on health insurance will continue under legislation signed by Gov. Rick Snyder. The bill enacted Tuesday extends the health insurance claims assessment, which helps pay for Medicaid for low-income residents, until July 2020. The tax would have gone away in two years if the legislation were not adopted. (3/17)

The Milwaukee Journal-Sentinel: Late Maneuvering In Senate Blocks Cannabidiol Measure
A bill to help anguished parents get a child seizure treatment failed to get a vote amid a hastily adjourned Senate session, even though a majority of senators support the proposal. (Stein and Spivak, 3/16)

The Associated Press: Arizona Supreme Court To Consider Marijuana Search Issue
The state Supreme Court plans to decide whether the mere smell of marijuana is enough to justify a search by police in the wake of Arizona's legalization of medical marijuana. The justices agreed Tuesday to consider appeals of contradictory rulings by the Phoenix and Tucson divisions of the state Court of Appeals. (3/16)

The Boston Globe: CDC In Boston To Investigate Illness Striking Homeless
Disease-trackers from the Centers for Disease Control and Prevention arrived in Boston Wednesday to study the spread of a deadly bacterial infection among homeless people. Dr. Anita Barry, director of the Infectious Disease Bureau at the Boston Public Health Commission, said the CDC is interested in the city’s experience because the federal agency is updating guidelines for handling clusters of meningococcal disease, the infection that killed two homeless people in Boston and sickened three others. (Freyer, 3/16)

The Milwaukee Journal-Sentinel: 2 More Wisconsin Deaths Tied To Elizabethkingia Anophelis Reported
Seventeen people with infections caused by Elizabethkingia bacteria have died since the outbreak began in Wisconsin in November, an increase of two from last week, the state Department of Health Services reported Wednesday. The number of cases, which are spread across 12 counties, also increased, from 48 to 54. (Stephenson and Rutledge, 3/16)

Minnesota Public Radio: New Minnesota Research Links Low Income, Diabetes
Low-income adults in Minnesota are much more likely to develop diabetes than people with higher incomes, according to the Minnesota Department of Health. New research shows that 13 percent of working-age Minnesotans who earn less than $35,000 annually have diabetes. That compares to a diabetes rate of just 5 percent for earners who make more than $35,000. (Benson, 3/16)

The Associated Press: Bismarck Hospital Won't Close Inpatient Pediatric Unit
A hospital in North Dakota's capital on Wednesday rescinded its decision to close its pediatric inpatient unit, two days after the closure was announced. CHI St. Alexius Health in Bismarck said in a statement that the unit will remain open, but the health system will still go ahead with its plans to lay off 23 employees, reassign others and close the inpatient rehabilitation unit for adults. (3/16)

The Gazette: Monument Will Pay Methadone Provider $350,000 To Stay Out Of Town
Monument must pay a methadone provider $350,000 under a settlement that would keep the company from opening a facility there, the town's manager said Wednesday. The figure offered the first glimpse at how much taxpayers must pay to settle with Colonial Management Group - which sued Monument last year after town officials denied the company a business license and issued a moratorium on clinics opening in or around downtown. (Rodgers, 3/16)

Vox: Fatal Mistakes
Medical errors kill more people each year than plane crashes, terrorist attacks, and drug overdoses combined. And there's collateral damage that often goes unnoticed: Every day, our healers quietly live with those they have wounded or even killed. Their ghosts creep into exam rooms, their cries haunt dreams, and seeing new patients can reopen old wounds. (Sarah Kliff, 3/15)

Pacific Standard: The Youngest Casualties In The War On Obesity
Around the country, many psychologists and families are noticing an increasing number of children and teenagers with eating disorders that appear to be triggered by school-based obesity-prevention programs, ranging from discussions of healthy food in class to so-called "BMI report cards" that report a child's body mass index in a letter to parents. (Carrie Arnold, 3/14)

The Atlantic: A Pill For Down Syndrome
Myelin is the white substance that coats axons, the spokes than connect neurons to one another. A reduction in myelin has been linked to a variety of neurological conditions, including multiple sclerosis and Guillain-Barre syndrome, among others. And a few drugs related to myelin production are already in clinical trials, which means that what was once a parlor game—would you take away the Down syndrome?—may one day be a reality for parents like us. If and when drugs are developed that reverse myelin loss specifically in people with Down syndrome, we’ll join the many other parents of children with brain differences who face similar quandaries. (Amy Julia Becker, 3/15)

The California Health Report: As More California Counties Implement Laura’s Law, Advocates Push Back
Despite the fact that Laura’s Law was passed in California over 13 years ago, and that 44 other states have similar laws in place, adoption of Laura’s Law has been slow. Most counties who have attempted to adopt the law have faced strong opposition by mental health consumers, legal organizations and advocates from underserved and marginalized communities. The organization Disability Rights California has lobbied heavily against the law since 2002, threatening to sue counties that implemented Laura’s Law, saying assisted outpatient treatment doesn’t work. (Linda Childers, 3/15)

The Economist: Things Are Looking App
There are now around 165,000 health-related apps which run on one or other of the two main smartphone operating systems, Apple’s iOS and Google’s Android. PwC, a consulting firm, forecasts that by 2017 such apps will have been downloaded 1.7 billion times. However, the app economy is highly fragmented. Many providers are still small, and most apps are rarely, if ever, used. (3/12)

Vox: Uterus Transplants Are Extremely Risky. Doctors Should Keep Doing Them Anyway.
Lindsey's tragedy — after much fanfare — raises the question about whether it's really worth continuing with the operation at all. Though the doctors in Cleveland have nine additional uterus transplants in the works as part of an ongoing study, the procedure remains hugely controversial. I asked medical ethicists and doctors (including one of the authors of the global ethical guidelines for uterine transplants) for their opinion. They all pointed out that the uterine transplant is a supremely risky operation — but agreed that doctors and willing patients should continue experimenting with them anyway. (Julia Belluz, 3/10)

The New York Times: A Strong Response To The Opioid Scourge
The Centers for Disease Control and Prevention this week released well-reasoned guidelines for how doctors should prescribe opioid painkillers. The voluntary standards could make a difference in curbing the alarming increase in prescription drug deaths. ... To reduce this high toll, the C.D.C. is advising doctors not to prescribe opioids for chronic pain in most situations. Studies have found no evidence that the long-term use of opioids is beneficial, and in fact, exercise, physical therapy and over-the-counter drugs like acetaminophen can be more effective. The guidelines do not apply to cancer treatment, palliative care and end-of-life care, situations in which opioids are often the only way to reduce pain. (3/17)

Bloomberg: Valeant Analysts Finally Wake Up
Valeant analysts are leading from behind. Sell-side analysts, many of whom have been Valeant's staunchest defenders, belatedly started to sour on the company Wednesday. It's akin to pouring a dixie cup on the remains of a bonfire. But after the spit-roasting of Valeant's stock -- down 50 percent -- and the company's shambolic earnings call on Tuesday, some analysts finally came to terms with exactly how broken this company is. (Max Nisen, 3/16)

Bloomberg: Drug Trials And Bank Heists
Back when it was a hedge fund, one thing that SAC Capital did was learn some negative results of a clinical trial of a drug about two weeks before those results were publicly announced, and then sell its stock in the drug company before the announcement. In a narrow sense this was a good trade, and SAC avoided several hundred million dollars of losses by getting out of the stock before the announcement. In a broader sense, this trade led to the end of SAC, which had to pay $600 million to the Securities and Exchange Commission, plead guilty to insider trading, and stop being a hedge fund because of it. Also the analyst responsible for the trade went to prison for nine years. (Matt Levine, 3/16)

The New England Journal Of Medicine: Health Care Tax Inversions — Robbing Both Peter And Paul
On November 23, 2015, Pfizer announced that it would merge with Ireland-based Allergan. The resulting organization, valued at about $160 billion, will be the largest pharmaceutical company in the world. The chief motive for the merger is financial: to avoid paying higher corporate taxes, U.S. companies have started to merge with smaller companies based in countries with lower tax rates to effectively become foreign companies. This strategy is known as “corporate inversion” or “tax inversion,” and it’s become particularly attractive for health care companies. (Haider Javed Warraich and Kevin A. Schulman, 3/17)

The New England Journal Of Medicine: Scandal As A Sentinel Event — Recognizing Hidden Cost–Quality Trade-Offs
In 2014, Americans reacted with outrage to reports that personnel at Veterans Health Administration (VA) medical centers had schemed to feign compliance with targeted waiting times for appointments. Whistle-blowers outed miscreants, alleging that clinical delays had caused scores of avoidable deaths. Political leaders blamed bad actors — and each other. Investigations led to firings — and congressional fury that not enough heads were rolling. The prevailing narrative was one of breakdowns of character and culture: dishonesty, callousness, and ineptitude. (M. Gregg Bloche, 3/17)

Louisville Courier-Journal: Former Apple CEO: Better Health Through Tech
When former Apple CEO John Sculley first joined that seminal company, he was struck by co-founder Steve Jobs’ vision of changing the world through the “noble cause” of personal computing. Now, he said, he’s “totally excited and passionate about” a new noble cause – using high-level technology to transform health care. (Laura Ungar, 3/17)

The New England Journal Of Medicine: Beyond The VA Crisis — Becoming A High-Performance Network
Overhauling the health care system for Americans who answered the call of duty by serving in the military is a national priority. In the spring of 2014, the Veterans Health Administration (VA) faced a crisis with regard to veterans’ access to care. Systemic problems in scheduling processes had been exacerbated by leadership failures and ethical lapses. Demand for services was outstripping capacity. The result was that veterans did not have timely access to the health care they had earned. (David J. Shulkin, 3/17)

Lexington Herald Leader: Alvarado’s Shameful Amendment
Ironies abound whenever the General Assembly meets, but Sen. Ralph Alvarado, R-Winchester, has provided one of the most profound and disturbing of this session. Alvarado, a physician, assured that more dirty hypodermic needles will be in circulation, spreading deadly blood-borne infections. He did this by attaching a noxious amendment in the Senate to a simple bill that had easily passed the House. (Timothy D. Easley, 3/16)