Researchers have developed a hybrid sperm micromotor, which can carry a payload and efficiently and controllably swim against flowing blood. Sperm-based micromotors hold several advantages, in particular their powerful propulsion generated by the beating of the sperm flagella. Sperm are also able to swim for several days with a drag force up to 100 pN. The most important feature of sperm micromotors to operate in the bloodstream is their ability to swim against flow as well as close to boundaries, where the blood velocity is lower than the average velocity, due to shear stress.