With their ability to resist conventional chemotherapy drugs, cancer stem cells (CSC) are really difficult to kill, and they are considered to be key drivers in metastasis, the spread of cancer via the blood stream. If the frequency of CSCs could be diminished, tumors would be rendered less aggressive and more responsive to conventional therapy. This approach is known as differentiation therapy and has considerable therapeutic potential. Scientists now report an approach capable of efficient differentiation of CSCs into non-CSC phenotypes.