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UPCOMING WEBINAR

Nonviral CRISPR-based knock-in of chimeric antigen receptor transgenes into T cells for cell therapy

Apr 3, 2025 | 11:00am ET / 8:00am PT

Join us for an insightful webinar on the latest advancements in cell and gene therapy, focusing on the innovative Cas9-CLIPT technology.

Cas9-CLIPT (Cleaved, Linearized with Protein Template) is a groundbreaking technology designed to improve the efficiency of genome editing. It involves using a circular plasmid with a single target sequence for the Cas9 ribonucleoprotein (RNP). During manufacturing, the Cas9-RNP binds and cleaves the Nanoplasmid, linearizing the double-stranded DNA (dsDNA) in vitro. This linearized template, bound to Cas9-RNP, is then delivered to cells to promote precise knock-in via homology-directed repair. This method significantly enhances the precision and efficiency of CAR T cell production.