June 27, 2020 : Issue #1048

TOP STORIES - Diabetes News & Research

Once-Weekly Basal Insulin Shows Promise

Coming of Age: Are Telephonic Diabetes Interventions Worth the Time?

Dulaglutide vs. Liraglutide – Does One Have Better Cardiovascular Outcomes?

Letter from the Editor

Although many of us would have liked to spend a week in Chicago at the ADA Scientific Sessions, the pandemic forced us to miss a chance to have some great food and fun. Although the live session is always good, it was kind of nice to do the sessions at your leisure via the web. One of the best parts was the opportunity to review things and share with others.

There was a study presented that looked at a once a week basal insulin. This grabbed me as a drug I wanted to learn more about, so I gave our intern, Lawand Kamal, PharmD Candidate 2021, Skaggs School of Pharmacy and Pharmaceutical Sciences, the project to teach me about this new insulin.

My thought process was that if this works, you give a patient one shot of insulin and a weekly GLP-1, and without a doubt you have the best 1-2 punch for managing type 2 diabetes. Check out what Lawand taught me by clicking here.

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We can make a difference!

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Dave Joffe

Editor-in-chief

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Fact: Will Once Weekly Basal Insulin Hit or Miss?

New research suggests that the investigational once-weekly basal insulin analog icodec (Novo Nordisk) was comparable in efficacy and safety to once-daily insulin glargine U100. But will patients make the change? Julio Rosenstock, MD, of University of Texas Southwestern Medical Center at Medical City, Dallas, presented the data at the ADA's Scientific Sessions last week. 

They found that insulin icodec has a 196-hour half-life. This insulin is designed to cover a person's basal insulin requirements for a full week with a steady insulin release. We know that most people with T2D are reluctant to start on insulin due to the need for daily injections. This was a phase 2 study, and we need to wait until phase 3 data is completed before making any final decisions. The primary endpoint, change in A1c from baseline to week 26, dropped 1.33 percentage points with icodec.

The difference between the two groups in moderate or clinically significant hypoglycemia wasn't statistically significant (P  = .85), and the duration of hypoglycemia wasn't longer with icodec compared with glargine, despite its longer duration of action, Rosenstock explained.

If the data is confirmed in the phase 3 study, "I believe personally that weekly basal insulin has the potential to be transformational in the management of people with type 2 diabetes needing insulin therapy." See item #1

ADA 2020 Scientific Sessions. Presented June 14, 2020. Abstracts 236-OR, 237-OR, 238-OR.

Diabetes in Control gratefully acknowledges the assistance of the following pharmacy doctoral candidates in the preparation of this week’s newsletters:

David Clarke, PharmD Candidate, University of Colorado, Skaggs School of Pharmacy and Pharmaceutical Sciences

Kenya Henderson, 2021 PharmD. Candidate, Florida Agricultural & Mechanical University, College of Pharmacy and Pharmaceutical Sciences

Lawand Kamal, PharmD Candidate 2021, Skaggs School of Pharmacy and Pharmaceutical Sciences

Jacob Roberts, PharmD Candidate 2021 of University of Colorado Denver Skaggs School of Pharmacy and Pharmaceutical Sciences

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June 27, 2020 : Issue #1048

TOP STORIES - Diabetes News & Research

TOP STORIES - Diabetes News and Research

Fact: Will Once Weekly Basal Insulin Hit or Miss?

Diabetes in Control gratefully acknowledges the assistance of the following pharmacy doctoral candidates in the preparation of this week’s newsletters: