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ScienceDaily: Mind & Brain News |
| Researchers discover a dependency of glioblastoma on biotin distribution Posted: 15 Sep 2021 05:58 AM PDT Researchers have discovered that the FDA-approved anti-fungal drug, sulconazole, exhibits anti-cancer properties towards glioblastoma cells. An in-depth investigation of this compound revealed that it competes with biotin (Vitamin H), an important co-factor for metabolic enzymes and modifier of histones, allowing it to inhibit the normal function of biotin-dependent metabolic enzymes and specific histone modification-associated gene expression. |
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