ScienceDaily: Mind & Brain News

A combined analysis of results from 149 earlier studies finds that treatment rates for major depressive disorder remain low worldwide, particularly for people living in low and lower-middle income countries.

Researchers created a comprehensive atlas of the types of cells found in the brain cerebrovasculature, which provides oxygen and nutrients to the brain and helps form the blood-brain barrier. They also found significant differences between healthy cells and those from Huntington's disease patients.

Receiving at least one vaccine dose was associated with statistically significant declines in multiple psychological distress factors, researchers report in a new study.

Researchers have discovered that the protein YME1L regulates the production of new nerve cells and the maintenance of neural stem cells in the adult brain. This holds great potential for regenerative treatments after brain injuries and other diseases.

In a new, rare study of direct brain recordings in children and adolescents, scientists have discovered as brains mature, the precise ways by which two key memory regions in the brain communicate make us better at forming lasting memories. The findings also suggest how brains learn to multitask with age. Historically, a lack of high-resolution data from children's brains have led to gaps in our understanding of how the developing brain forms memories. The study innovated the use of intracranial electroencephalogram (iEEG) on pediatric patients to examine how brain development supports memory development.

Researchers have developed and characterized a new cell model for Alzheimer's disease that has wide utility for research and could prove useful in early diagnosis and testing of new therapies.

A novel probe developed in 2017 allowed unprecedented recording of brain activity but only in small lab animals. MGH researchers and colleagues have successfully used a modified version of the probe to measure brain activity in humans. Insights gleaned from data acquired by this modified tool could have profound implications for the understanding of how the brain functions in good health and in disease.

New findings support the view that hyperactive immune cells in the brain can have a protective effect in the course of neurodegenerative diseases.

While the word 'mutation' may conjure up alarming notions, a mutation in brain immune cells serves a positive role in protecting people against Alzheimer's disease. Now biologists have discovered the mechanisms behind this crucial process.

Researchers have uncovered a new pathway that helps explain how consuming too much alcohol causes damage to the liver, specifically mitochondrial dysfunction in alcohol-associated liver disease.

Coils and stents less invasively repair brain aneurysms, but are they superior to clips implanted during surgery? A study compares the treatments.

A new study shows how a particular molecule, produced by gut bacteria, affects brain function and promotes anxiety-like behaviors in mice.

The brain has neurons that fire specifically during certain mathematical operations. The findings indicate that some of the neurons detected are active exclusively during additions, while others are active during subtractions. They respond in the same manner whether the calculation instruction is written down as a word or a symbol.

Minor everyday rises in blood pressure due to short-term stressors can be linked to a brain area that controls conscious and learned motor skills. This discovery paves the way for a chance to influence the rises in blood pressure and, in the long run, prevent hypertension.

Increased oxidative damage is linked to neurodegenerative disorders such as Alzheimer's disease (AD). Even though the pathophysiology of AD has been widely investigated, the likely relationship between mitochondrial dysfunction and the disease remains largely unknown. A research team has now confirmed that AD progression is linked to oxidative brain damage, which impairs cognitive function in AD transgenic mice in an age-dependent manner.