ScienceDaily: Top Health News


Effectiveness of antibiotics significantly reduced when multiple bugs present

Posted: 19 Mar 2022 05:16 AM PDT

A study has found that much higher doses of antibiotics are needed to eliminate a bacterial infection of the airways when other microbes are present. It helps explain why respiratory infections often persist in people with lung diseases such as cystic fibrosis despite treatment.

Researchers map human sensory neurons, pursue chronic pain cure

Posted: 18 Mar 2022 02:05 PM PDT

An investigation into how human sensory neurons differ from animal neurons has provided researchers with important clues in the pursuit of more effective treatments for chronic pain. Researchers are analyzing the origins of how pain is generated by nociceptors in human dorsal root ganglia (DRG) neurons, charting the full transcriptome of messenger RNA strands produced in these cells.

Exploring the therapeutic uses of ketamine

Posted: 18 Mar 2022 01:14 PM PDT

First manufactured more than 50 years ago, ketamine is a fast-acting dissociative anesthetic often used in veterinary and emergency medicine. Ketamine also has a history of being an illicit party drug. Now, ketamine is getting a closer look.

Antabuse may help revive vision in people with progressive blinding disorders

Posted: 18 Mar 2022 01:14 PM PDT

Animal and cell studies show that as retinal cells die in degenerative eye diseases, they make other cells hyperactive, creating noise that further obscures vision. Tests to prove this in humans are hard to conduct, however. Antabuse, an approved drug used to wean people off alcohol, should tamp down this hyperactivity and conclusively show whether hyperactivity plays a role in humans, potentially driving work to find better drugs to help those with progressive vision loss.

Piezo1 possible key to supporting muscle regeneration in Duchenne Muscular Dystrophy

Posted: 18 Mar 2022 01:14 PM PDT

Tracing the impact of a single protein, Piezo1, researchers found that restoring it in muscles affected by Duchenne muscular dystrophy could improve their ability to heal efficiently.

When the brain sees a familiar face

Posted: 18 Mar 2022 01:14 PM PDT

Researchers have uncovered new information about how the area of the brain responsible for memory is triggered when the eyes come to rest on a face versus another object or image.

Youngest brain tumor patients have significantly poorer outcomes than older pediatric patients

Posted: 18 Mar 2022 01:14 PM PDT

A researcher has found, through extensive data analysis, that the youngest patients with brain tumors -- those ages birth to 3 months -- have about half the five-year survival rate as children ages 1 to 19.

Lung tissue from the lab

Posted: 18 Mar 2022 01:14 PM PDT

An international research team has found a simple method for growing lung tissue in the lab. These organoids could be used in diagnosis, drug development, and fundamental research. Laboratory studies of lung tissue usually require the removal of large amounts of human or animal tissue. Now scientists have generated tiny quantities of lung tissue, so-called organoids, from just a few body cells in the lab. The tissue forms a three-dimensional structure as it develops, complete with the tiny hairs on the surface typical of lung tissue. These organoids can play an important part in future research on lung diseases, drug development, or personalized medicine.

New strategy reduces brain damage in Alzheimer’s and related disorders, in mice

Posted: 18 Mar 2022 10:16 AM PDT

Alzheimer's disease is the most common and best known of the tauopathies, a set of neurodegenerative brain diseases caused by toxic tangles of the protein tau. A study has now shown that targeting astrocytes -- an inflammatory cell in the brain -- reduces tau-related brain damage and inflammation in mice.

Natural COVID-19 antibodies lasts seven months for children, according to new study

Posted: 18 Mar 2022 10:16 AM PDT

Children previously infected with COVID-19 develop natural circulating antibodies that last for at least seven months, according to a new study.

Little evidence on how psilocybin therapy interacts with existing psychiatric treatments, review finds

Posted: 18 Mar 2022 10:16 AM PDT

As Oregon embarks on a voter-approved initiative to permit psychoactive mushrooms in clinical use, a new systematic evidence review reveals a lack of scientific research describing the interactions between widely used psychiatric medications and psychedelics like psilocybin and MDMA.

Early English lessons have lasting effects

Posted: 18 Mar 2022 07:49 AM PDT

An earlier study had raised doubts about the effectiveness of learning English in the first grade. Now, researchers have observed that it improves language performance over an extended period of time.

How gene expression changes in the brain in Alzheimer's disease

Posted: 18 Mar 2022 06:21 AM PDT

An international group of researchers analyzed the genes that are expressed in neurons and astrocytes based on data from 800 individuals and compared what happens in Alzheimer's patients and in people without diagnosed dementia. The study highlights the need to analyze molecular markers, such as genetic sequences or brain proteins, to obtain more accurate assays, diagnoses and therapies. The results also show changes in astrocytes in an attempt to adapt to the toxic environment derived from the disease, worsening its progression.

Higher exposure to bisphenol A in the womb associated with increased risk for asthma and wheezing in school-age girls

Posted: 18 Mar 2022 05:02 AM PDT

An analysis of data from more than 3,000 mother-child pairs from six European countries indicates that prenatal exposure to bisphenol A may have negative effects on respiratory health in school-age girls.

NIH's All of Us Research Program releases first genomic dataset of nearly 100,000 whole genome sequences

Posted: 17 Mar 2022 04:32 PM PDT

Nearly 100,000 highly diverse whole genome sequences are now available through the National Institutes of Health's All of Us Research Program. About 50 percent of the data is from individuals who identify with racial or ethnic groups that have historically been underrepresented in research. This data will enable researchers to address yet unanswerable questions about health and disease, leading to new breakthroughs and advancing discoveries to reduce persistent health disparities.

Harassment of public health officials widespread during the initial phase of the COVID-19 pandemic, study finds

Posted: 17 Mar 2022 02:25 PM PDT

Among local and state public health officials who resigned or were fired during the first 11 months of the pandemic, more than one-third reported incidents of harassment, a new study finds.

Bone marrow cancer: Potential drug targets

Posted: 17 Mar 2022 02:24 PM PDT

New research finds that patients with ASXL1-mutant chronic myelomonocytic leukemia -- an uncommon type of cancer of the bone marrow -- have distinctive epigenetic changes that can activate harmful genes and cause the cancer to grow faster. The ASXL1 genetic mutation also can transform the disease into the more aggressive acute myeloid leukemia.

Physicists find direct evidence of strong electron correlation in a 2D material

Posted: 17 Mar 2022 01:36 PM PDT

MIT physicists have detected electron correlations in a 2D material called ABC trilayer graphene. Understanding how electron correlations drive electrical states can help scientists engineer exotic functional materials, such as unconventional superconductors.

How coronavirus triggers immune response in brain

Posted: 17 Mar 2022 01:36 PM PDT

A new study describes how the spike protein used by the coronavirus to enter human cells can have a similar effect on the brain's immune cells as it does with the rest of the body.

Chemists find a quick way to synthesize novel neuroactive compounds found in rainforest tree

Posted: 17 Mar 2022 11:37 AM PDT

A potential cornucopia of neuroactive compounds, which might yield clues to the design of future psychiatric and neurological drugs, has become more accessible to synthetic chemists.

Pioneering technique could unlock targeted treatments for cancer

Posted: 17 Mar 2022 11:37 AM PDT

Researchers have described application of a pioneering chemical technique which could unlock ground-breaking new treatments for cancer and other diseases.

Lighting the way to healthier daily rhythms

Posted: 17 Mar 2022 11:37 AM PDT

A new report addresses the issue of exactly how bright lighting should be during the day and in the evening to support healthy body rhythms, restful sleep, and daytime alertness.

Lithium may decrease risk of developing dementia

Posted: 17 Mar 2022 11:37 AM PDT

Researchers have identified a link suggesting that lithium could decrease the risk of developing dementia, which affects nearly one million people in the UK.

Long-suspected turbocharger for memory found in brain cells of mice

Posted: 17 Mar 2022 11:32 AM PDT

Scientists have long known that learning requires the flow of calcium into and out of brain cells. But researchers have now discovered that floods of calcium originating from within neurons can also boost learning. The finding emerged from studies of how mice remember new places they explore.

Scientists discover why women are more resistant to nonalcoholic fatty liver disease than men

Posted: 17 Mar 2022 09:04 AM PDT

Nonalcoholic fatty liver disease (NAFLD) is one of the leading causes of death worldwide. However, why premenopausal women are more resistant to NAFLD than men is currently unknown. Now, scientists demonstrate, through sex-balanced experiments on mice, that the female liver produces higher levels of a protein that has a protective effect against NAFLD. Their findings could lead to new therapeutic strategies for treating NAFLD.

AI provides accurate breast density classification

Posted: 17 Mar 2022 09:04 AM PDT

An artificial intelligence (AI) tool can accurately and consistently classify breast density on mammograms, according to a new study.

Researchers put a spotlight on aggressive cancer cells

Posted: 17 Mar 2022 09:03 AM PDT

Metastases in cancer are often caused by a few abnormal cells. These behave more aggressively than the other cancer cells in a tumor. Researchers are now on a method to detect these cells.

Radical increase in the effectiveness of breast cancer immunotherapy

Posted: 17 Mar 2022 09:03 AM PDT

Researchers have discovered the essential role of a new factor, LCOR, in enabling cancer cells to present tumor antigens on their surfaces. These antigens allow the immune system to recognize the tumor, an essential step if immunotherapy treatment is to succeed. On the other hand, they have shown that cancer stem cells have very low levels of LCOR, making them invisible to the immune system and therefore resistant to treatment.

Engineering an 'invisible cloak' for bacteria to deliver drugs to tumors

Posted: 17 Mar 2022 09:03 AM PDT

Researchers have genetically engineered a microbial encapsulation system for therapeutic bacteria that can hide them from immune systems, enabling them to reach tumors more effectively and kill cancer cells in mice.

In U.S., alcohol use disorder linked to 232 million missed workdays annually

Posted: 17 Mar 2022 08:19 AM PDT

Researchers have found that people with severe alcohol use disorder miss more than double the number of workdays missed by individuals without alcohol use disorder.

Delta breakthrough infection generates broad neutralizing antibody response in double vaccinated individuals

Posted: 17 Mar 2022 08:19 AM PDT

A delta breakthrough infection generates a potent and broad neutralizing antibody response to SARS-CoV-2 in double vaccinated individuals, according to new research.

Creutzfeldt-Jakob disease treatment shows promising early results

Posted: 17 Mar 2022 08:19 AM PDT

A promising new treatment for Creutzfeldt-Jakob disease (CJD) has shown 'very encouraging' early results following its use in six patients.

Large study on traumatic brain injury highlights global inequality in causes and treatment

Posted: 17 Mar 2022 08:19 AM PDT

A large study examining the surgical management of traumatic brain injuries highlights regional inequalities in both major causes and treatment of such injuries.

A gene could prevent Parkinson's disease

Posted: 17 Mar 2022 08:19 AM PDT

Parkinson's disease is a neurodegenerative disorder characterized by the destruction of a specific population of neurons: the dopaminergic neurons. A team has investigated the destruction of these dopaminergic neurons using the fruit fly as study model. The scientists identified a key protein in flies, and also in mice, which plays a protective role against this disease and could be a new therapeutic target.

Obesity: A dangerous immune response

Posted: 17 Mar 2022 08:19 AM PDT

Researchers show which molecular processes promote secondary diseases in obesity.

Extended napping in seniors may signal dementia

Posted: 17 Mar 2022 08:18 AM PDT

Daytime napping among older people is a normal part of aging -- but it may also foreshadow Alzheimer's disease and other dementias. And once dementia or its usual precursor, mild cognitive impairment, are diagnosed, the frequency and/or duration of napping accelerates rapidly, according to a new study.

New PCR test can identify all SARS-CoV-2 variants in a positive patient sample

Posted: 17 Mar 2022 08:18 AM PDT

As SARS-C0V-2 variants emerged, researchers developed a PCR test that uses molecular beacons not only to diagnose COVID-19 infection, but also to identify the specific variant causing that infection.

Plasma biomarker screening could improve accuracy, health equity in Alzheimer’s disease diagnosis

Posted: 17 Mar 2022 08:18 AM PDT

A new study focuses on RNA molecules in plasma as biomarkers for Alzheimer's disease in African Americans -- the population at greatest risk for developing Alzheimer's disease. This approach enabled researchers to pinpoint specific molecules in plasma that could serve as biomarkers to confirm a diagnosis of Alzheimer's disease in this population.

Alzheimer’s: Protective immune cells active decades before symptom onset

Posted: 17 Mar 2022 06:47 AM PDT

In individuals with a genetic predisposition to Alzheimer's disease, the immune cells of the brain -- the 'microglia' -- start exerting a protective effect up to two decades before the first symptoms appear. A team draws this conclusion based on a study of more than 200 volunteers. In light of their study data, the scientists consider modulating the activity of microglia to be a promising therapeutic approach. To this end, they aim to develop drugs that target a cellular receptor called TREM2.

New study finds higher rates of newly diagnosed type 2 diabetes after infection with mild COVID-19

Posted: 17 Mar 2022 06:47 AM PDT

New research suggests a possible association between mild COVID-19 cases and subsequently diagnosing type 2 diabetes.

Mother to child transmission of COVID-19 infection, possible but rare, study finds

Posted: 17 Mar 2022 06:47 AM PDT

SARS-CoV-2, the virus causing the COVID-19 infection, can be transmitted from mother to baby before, during and after childbirth -- but such occurrences are rare, a new study reveals.

If blood pressure rises upon standing, so may risk for heart attack

Posted: 17 Mar 2022 06:47 AM PDT

Young and middle-aged adults with high blood pressure whose systolic blood pressure (top-number) rose more than 6.5 mm Hg upon standing were more likely to later have a heart attack, stroke, heart-related chest pain or other major heart disease-related event than those with lower systolic blood pressure in response to standing. The researchers highlight the importance of measuring standing blood pressure in young and middle-aged adults with hypertension, suggesting early treatment for those who have elevated blood pressure upon standing.

Scientists identify neurons in the brain that drive competition and social behavior within groups

Posted: 16 Mar 2022 02:32 PM PDT

In mice, social ranking in a group was linked to the results of competition, and certain neurons in the brain stored this social ranking information to inform decisions. Manipulating the activity of these neurons could increase or decrease an animal's competitive effort and therefore control their ability to successfully compete against others.

Blood test may indicate higher risk pregnancies in patients with COVID-19

Posted: 16 Mar 2022 02:32 PM PDT

A small preliminary study has shown that a blood test may identify risk of stillbirth and placentitis in pregnant individuals who have had COVID-19. The finding builds on another study with similar results and could have implications in how physicians screen for and address high-risk pregnancies.

Inhalable 'aerogel' triggers immunity to COVID-19 in mice, may block transmission

Posted: 16 Mar 2022 11:58 AM PDT

An inhalable 'aerogel' loaded with DNA that encodes for the SARS-CoV-2 spike protein successfully induces an immune response against COVID-19 in the lungs of mice, according to new research. The team said its aerogel could be used to create an inhalable vaccine that blocks SARS-CoV-2 transmission by preventing the virus from establishing an infection in the lungs.

Study reveals how to activate the immune system’s natural killer cells to protect against cancer and other diseases

Posted: 16 Mar 2022 11:57 AM PDT

Collagens and elastin in the extracellular matrix, which forms a scaffold to support organs, cause the immune system's natural killer cells to switch off their 'killer' function. The hypertension drug losartan can cause a previously resistant melanoma to become sensitive to natural killer cells by blocking collagen deposition in the tumor.