SHOT. CHASER. The UK has become the first place to authorise a COVID-19 vaccine and will begin vaccinations next week after the government’s independent scientific advisory body, the Medicines and Healthcare products Regulatory Agency, granted temporary authorisation for emergency use for Pfizer-BioNTech’s mRNA vaccine. MHRA announced the news yesterday after starting a “rolling review” in October of all available data and after Pfizer and BioNTech confirmed on November 18 that final efficacy analysis of their phase three study demonstrated 95% efficacy. Now, The Guardian reports UK Health Secretary Matt Hancock said the country will have 800,000 doses — enough for 400,000 people, with two jabs required for immunisation — available for deployment next week. Hancock also said a network of 50 hospitals capable of keeping the drug at -70C is ready to deliver the first jabs, while specialist vaccination centres are being built. Distribution will then be prioritised according to guidance from the Joint Committee on Vaccination and Immunisation, which advises that first priorities should be the “prevention of COVID-19 mortality and the protection of health and social care staff and systems” — i.e. elderly, immunocompromised, frontline care workers — and secondly those at increased risk of hospitalisation or exposure, and/or people required to maintain essential public services. Finally, the committee specifies there is no data as yet on the safety of COVID-19 vaccines in pregnancy, “either from human or animal studies”, and, favouring a precautionary approach, does not currently advise vaccination in pregnancy. PS: On the local front, Health Minister Greg Hunt has welcomed the news and noted that Pfizer continues to work with the TGA, while the government’s advice “remains that the timeline for a decision on approval is expected by the end of January 2021, and our planning is for the first vaccine delivery in March 2021”. |