Update to the Guidelines for the Prevention and Treatment of Opportunistic Infections in Children With and Exposed to HIV  Major revisions within the last 6 months are as follows:Â - Updated the literature for bacterial infections in children with HIV and children who were exposed to HIV but not infected, including epidemiology, infection risk and vaccine recommendations.
- Added vaccine recommendations for the use of pneumococcal vaccines PCV15, PCV20, and PPSV23 in children with HIV.
- Updated recommendations for the diagnostics and management of bacterial infections with considerations made for newer technology (including molecular testing), antimicrobial stewardship, and changes in relevant treatment guidelines. Â
- Recommended hepatitis C virus (HCV) RNA testing for infants between 2 to 6 months with perinatal HCV exposure.
- Added information and recommendations supporting the use of pangenotypic direct-acting antivirals (DAAs) in children aged 3 years and older. Â
- Noted treatment for HCV during pregnancy can be considered with shared decision-making.Â
All updates are developed by the subject matter groups listed in Appendix C of the guidelines and reviewed by editors and relevant outside reviewers before finalization. |
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