Week 6 kicks off with a matchup between NYG and NE that could've featured Fantasy starters Saquon Barkley, Evan Engram, and Sterling Shepard. Instead, due to various injuries, the Giants skill players have minimum Fantasy appeal, whereas Patriots weapons Sony Michel, James White and Josh Gordon are all solid plays.

We take a look at tonight's matchup, as well as every other game on the Week 6 slate, in our Starts & Sits, Sleepers & Busts and Start 'Em & Sit 'Em columns. Is Gardner Minshew worth starting over Aaron Rodgers? Why is Jamey touting Kyler Murray as a top 5 play this week?

Additionally, key Fantasy players missed practice on Wednesday, including Todd Gurley, David Johnson and Christian McCaffrey. We analyze the Fantasy impact of these injuries and more in our News & Notes piece.

Dave Richard goes through every game on the schedule for Week 6, identifying risky plays, sneaky sleepers and more for your Fantasy lineup.

The Giants will be undermanned on Thursday Night Football, while Fantasy players could be down two huge names at running back. Chris Towers catches you up on all the latest news.

Kyler Murray started to show his upside last week, but he's ready to take his game to a whole other level in Week 6, Jamey Eisenberg says.