We usually refer to running back handcuffs as lottery tickets, but they're really more like insurance policies. You play the lottery and you either win or lose, but an insurance policy is there whenever you need it most. And right now, we need Alexander Mattison, Jamey Eisenberg's Start of the Week for Week 6.  

Dalvin Cook isn't expected to play in Week 6, and this is exactly the situation you drafted Mattison for. The Vikings have, if anything, only grown more run-heavy this season, despite playing from behind plenty in their first five games. That shouldn't be the case this week, with a matchup against the winless Falcons on the way. Mattison rushed for 112 yards on 20 carries and added three catches for 24 yards in Week 5 against the Seahawks, despite playing less than half the team's snaps with Cook leaving early. He figures to see a ton of work in both the running and passing game, and should probably be viewed as a top-five running back this week. Cook should be back after the Week 7 bye, but for at least one week, Mattison is one heck of an insurance policy. 

We'll go through the rest of Jamey's Start 'Em & Sit 'Em column here, with advice for quarterback, running back, and wide receiver for a few picks below, and you can head here to read the full column. I'll be back tomorrow morning with Dave Richard's picks for every game on the NFL schedule in Week 6 plus an update on some of the key injuries around the league. And since there's no Thursday Night Football this week, I'll do another mailbag with your questions, so send them to Chris.Towers@CBSInteractive.com with the subject line "#AskFFT" and I'll answer them tomorrow morning. 

Start 'Em: Matthew Stafford and Ryan Fitzpatrick

"Stafford went into his Week 5 bye averaging 25.0 Fantasy points in his previous two games, and he should stay hot against the Jaguars. Every quarterback against Jacksonville this year has either multiple touchdowns or 300 passing yards, and this defense has allowed 659 yards in the past two games against Joe Burrow and Deshaun Watson."

Sit 'Em: Joe Burrow and Carson Wentz

"Burrow comes into Week 6 against the Colts with a combined 21 Fantasy points in his past two games against Jacksonville and Baltimore, and he should struggle again this week. The Colts are No. 2 in fewest Fantasy points allowed to opposing quarterbacks, and they are the only team in the NFL with more interceptions (nine) than passing touchdowns allowed (seven)."

Start 'Em: David Montgomery and Myles Gaskin

"Montgomery only has 10 carries in each of his past two games against Indianapolis and Tampa Bay, and he's rushed for just 56 yards and one touchdown over that span. But that's not what you should look at, especially since the Colts and Buccaneers have two of the best run defenses in the NFL. Instead, focus on Montgomery getting 10 catches for 60 yards on 14 targets in the two games without Tarik Cohen (ACL). If his involvement in the passing game continues, which it should, he will be fantastic for the rest of the year. And this week he's facing a Panthers team that has allowed a running back to score in four of five games this season."

Sit 'Em: Mark Ingram and Darrell Henderson

"Sean McVay plans to give more work to Cam Akers, and Malcolm Brown will still get touches. That could make Henderson risky to trust as anything more than a flex. Now, he did well in Week 5 at Washington while sharing time with Akers and Brown, and Henderson had 15 carries for 38 yards and a touchdown, along with three catches for 30 yards and a touchdown on four targets. But this is a tougher matchup against the 49ers, and we saw two weeks ago against the Giants that McVay isn't afraid to go away from Henderson after he was limited to nine total touches in that outing."

Start 'Em: Jamison Crowder and A.J. Brown

"The lone bright spot for the Jets on offense this season has been Crowder, who has at least seven catches and 100 yards in all three games he's played. He also has two touchdowns, and he has scored at least 17 PPR points in each outing. Even though Joe Flacco will start again for the injured Sam Darnold (shoulder), you should still start Crowder with confidence in all leagues. Miami has allowed five receivers to score at least 12 PPR points in its past four games."

Sit 'Em: D.J. Moore and Travis Fulgham

"I thought Moore would play well in Week 5 at Atlanta, and he delivered with four catches for 93 yards and a touchdown. But he only had five targets in the game and has combined for 15 targets in his past three outings. The touchdown was also his first of the season. Robby Anderson has emerged as the No. 1 receiver for the Panthers, and he's worth starting in all leagues. Moore should be considered a high-end No. 3 Fantasy receiver against the Bears, who have allowed just one touchdown to opposing receivers this year."