With Saquon Barkley missing another week, David Johnson battling a back injury, and four teams on bye, the Waiver Wire is extremely important going into Week 6. Waivers can also be scoured for long-term value this week, as it's a great time to add potential league-winning handcuffs like Alexander Mattison, Reggie Bonnafon and Gus Edwards.

Additionally, Monday Night Football brought us another dominant performance from the 49ers running backs. While Matt Breida broke off a huge TD run on the first play from scrimmage, did Tevin Coleman earn a significant workload as well? We take a deep dive into the SF RB situation, break down Melvin Gordon and Austin Ekeler usage, and dissect the Chiefs RBs in our Stealing Signals and RB Preview columns.

With Saquon Barkley and David Johnson potentially out in Week 6, their replacements should be your top priorities on the waiver wire, Jamey Eisenberg says.

Ben Gretch focuses on what matters for Fantasy players as he recaps every game from Week 5.

Heath Cummings gives you everything you need to know about Week 6 including waiver priorities and DFS plays.