Discover our latest cancer research breakthroughs ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏
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| | Dear Voornaam, This year, for the first time, we have a special issue of Search, our supporter magazine. This issue of Search showcases our quest to discover and develop new cancer treatments, taking you behind the scenes of drug creation – from designing new drugs to testing them in clinical trials. Download your digital copy below. |
| | | | | Dr Joanna Loizou - Deputy Director, Centre for Target Validation |
| Drug discovery has never been more exciting, and with each new treatment, we are getting closer to defeating cancer. Our innovative research techniques, diversity of scientific backgrounds and creativity in our labs is helping improve the success rate of new drugs, providing personalised, kinder treatments to patients around the world. “At the ICR, I’m able to interact with an interdisciplinary team of amazing biologists, chemists, pharmacologists, medics and computer scientists, all of whom are working together to achieve the same goal but addressing the problem from different angles.” |
| | | But how do we discover these treatments? |
| | | Understanding the biology of cancer Our researchers need to uncover the cellular and molecular changes underpinning different types of cancers, the genetic mutations that alter their appearance or behaviour, and the complex interactions between the immune system and cancer. |
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| | | Designing new cancer drugs Small molecule drugs are revolutionising treatments, by targeting proteins that are essential for cancer cell function, including growth, signalling and survival. Their low molecular weight allows them to enter cells easily, so they can target cancer at its foundations. |
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| | | The detail behind how drugs are designed The key to effective treatments is understanding the atomic structure of a protein in a cancerous cell. This part of the drug discovery requires high resolution imaging, from X-ray crystallography to cryo-electron microscopy (cryo-EM). |
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| | | Taking our pioneering drugs into clinical trials Collaboration between clinical and laboratory teams is how drugs like NXP800 are made. Currently in clinical trials for ovarian cancer, and showing promising results for advanced prostate cancer, this new drug could offer people life-changing treatment. |
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| | Drug discovery and development is complex, with no single treatment working for every type or every individual. But our research techniques are becoming increasingly sophisticated and innovative, and we want to keep pushing the boundaries of what's possible.
This extraordinary scale requires extraordinary people to support our work. You are one of them. A monthly donation could aid us along each of these stages of drug discovery and help find more cures, saving more lives. |
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| | With warm wishes, Catherine Graham
Joint Head of Fundraising Campaigns and Individual Giving
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